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{
    "metadata": {
        "accession": "F8JSF4",
        "id": "F8JSF4_STREN",
        "source_organism": {
            "taxId": "1003195",
            "scientificName": "Streptantibioticus cattleyicolor (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057)",
            "fullName": "Streptantibioticus cattleyicolor (strain ATCC 35852 / DSM 46488 / JCM 4925 / NBRC 14057 / NRRL 8057)"
        },
        "name": "DNA gyrase subunit A",
        "description": [
            "A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner"
        ],
        "length": 866,
        "sequence": "MADETPITPEGSPTPVTPQGGPATVEGVGLRVEPVGLETEMQRSYLDYAMSVIVSRALPDVRDGLKPVHRRVLYAMYDGGYRPEKGFYKCARVVGDVMGTYHPHGDASIYDALVRLAQSWAMRMPLVDSNGNFGSPGNDPAAAMRYTECKMAPLSMEMVRDIDEETVDFQDNYDGRNQEPTVLPSRFPNLLINGSAGIAVGMATNIPPHNLREVAEGAQWYLANPEASNEELLEALMERIKGPDFPTGALVVGRRGIEEAYRTGRGSITMRAVVEVEEIQNRQCLVVTELPYQVNPDNLAQKIADLVKDGRVGGIADVRDETSSRTGQRLVIVLKRDAVAKVVLNNLYKHTDLQTNFGANMLALVDGVPRTLSLDAFIRHWVTHQVEVIVRRTRFRLRKAEERAHILRGLLKALDAIDEVIALIRRSDTVEVARDGLMGLLEIDEIQANAILEMQLRRLAALERRKIVAEHDELQAKISEYNAILASPERQRGIISEELTALVEKFGDDRRSQLVPFDGDMSIEDLIAEEDIVVTITRSGYVKRTKTDDYRSQKRGGKGVRGTKLKEDDIVDHFFVTTTHHWLLFFTNKGRVYRAKAYELPDAGRDARGQHVANLLAFQPDEHIAQIMAVRDYEAAPYLVLATKSGLVKKTPLKDYDSPRSGGVIAINLREMADGREDELIGAELVGPDDDLLLISRKAQSIRFTATDESLRPMGRATSGVKGMSFREGDELLSMNVVRPGTFVFTATDGGYAKRTPVDEYRVQGRGGLGIKAAKIVEDRGSLVGALVVEETDEILAITLGGGVIRTRVNEIRETGRDTMGVQLINLGKRDAVVGIARNAEAGAEAEEVDADGAEGEQPPAGDPEE",
        "proteome": "UP000007842",
        "gene": "gyrA",
        "go_terms": [
            {
                "identifier": "GO:0003677",
                "name": "DNA binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0003918",
                "name": "DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005524",
                "name": "ATP binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006265",
                "name": "DNA topological change",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0006259",
                "name": "DNA metabolic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0003916",
                "name": "DNA topoisomerase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005694",
                "name": "chromosome",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "c36c28bc262440b563e8530b988ffbe4e710074b",
        "counters": {
            "domain_architectures": 26528,
            "entries": 24,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 1,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "smart": 1,
                "cdd": 1,
                "ssf": 2,
                "pfam": 2,
                "cathgene3d": 4,
                "profile": 1,
                "hamap": 1,
                "panther": 1,
                "ncbifam": 3,
                "interpro": 8
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 26528
        }
    }
}