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{
    "metadata": {
        "accession": "F7EMG7",
        "id": "F7EMG7_ORNAN",
        "source_organism": {
            "taxId": "9258",
            "scientificName": "Ornithorhynchus anatinus",
            "fullName": "Ornithorhynchus anatinus (Duckbill platypus)"
        },
        "name": "Calsyntenin-1",
        "description": [
            "As intracellular fragment AlcICD, suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding",
            "In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP",
            "Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation. Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane. Also functions as a cargo in axonal anterograde transport by acting as a molecular adapter that promotes KLC1 association with vesicles. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation"
        ],
        "length": 978,
        "sequence": "MPRPGRPLRPAPAPVPVPVPAWLLLFGLLCSGARAARVNKHKPWIETTYHGIVTENDNTVLLDPPLIALDKDAPLRFAGEICGFKIHGQDVPFDAVVVDKSTGEGIIRSKEKLDCELQKDYSFSIQAYDCGKGPDGAGVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKKYDNILKVEAVDADCSPQFSQICSYEIVTPDVPFTIDKDGYIKNTEKLNYGKGHQYKLTVTAFDCGKKRATEDVLVKISIKPTCRPGWQGWSKRIEYEPGTGSLALFPSIHLETCDEPITSIQATVELETNHIGKGCDRDTYSEKSLHRLCGASPGTAELLPPPSNTLNWTIGLPTDNGHDSDQVFEFNGTQAVKIPDGVVTVNMKEPFMISVWMRHGPGAKEKETILCNSDKTDMNRHHYSLYVHNCHLVFLLRQDPSEEKNYKPAEFHWKLNQVCDKEWHHYVLNVEFPSVTLFVDGVSYDPFPVTEDYPLHPSKVETQLVVGACWQEYTGSENDNETETVTVTYAGGELRMAQFFRGNLAGLMVRSGKLENKNVIDCLYTCKEGLDLQPADGIGKGLKIQANPGQSVLTLEGDDIERFDKAMQHISYLNSRQFPTPGIRRLKITSTIKCLNEEDCISAPLVDGYIMVLQPEEPKISLSGINHFARAASEFESPEGVSLFPELRIISTITREVEPEGDGDEDPTVQESLVSEEIMHNLDTCEVTVLGEELNPEQESLEVDMTRLQQKGIETSSSNLGMIITGVDTMASYEEVLHLIRYRNWHTMSLFDRKFKLVCSELNGRYVSNEFKVEVNVIHTANSGEHANHIAAQPQFVHPVHHSFVDLSGHNLANPHPFSVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHQQTLRDQDAGKENEMDWDDSALTITVNPMETYEDQHSSEEEEEEEEEESEDGEEDDDITSAESESSEEEEAGQEEDQQNVNRQQQLEWDDSTLSY",
        "proteome": "UP000002279",
        "gene": "CLSTN1",
        "go_terms": [
            {
                "identifier": "GO:0005509",
                "name": "calcium ion binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0016020",
                "name": "membrane",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            },
            {
                "identifier": "GO:0007156",
                "name": "homophilic cell-cell adhesion",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "9840455e5c0eb2988c810aad03f3790c417fd1a3",
        "counters": {
            "domain_architectures": 1677,
            "entries": 17,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "pfam": 3,
                "ssf": 2,
                "profile": 1,
                "cdd": 1,
                "cathgene3d": 2,
                "smart": 1,
                "panther": 1,
                "prints": 1,
                "interpro": 5
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 1677
        }
    }
}