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InterPro-Version: 108.0
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{
"metadata": {
"accession": "F7C1J2",
"id": "F7C1J2_MONDO",
"source_organism": {
"taxId": "13616",
"scientificName": "Monodelphis domestica",
"fullName": "Monodelphis domestica (Gray short-tailed opossum)"
},
"name": "Ubiquitin-like modifier-activating enzyme 1",
"description": [
"Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites"
],
"length": 1000,
"sequence": "MPGPLLTLTPTPSNPYWSISGQLGPGGDSGQNIILGGVKAVTLHDQGAAQWADLSSQFYLREEDVGKNRAEVSQPRLAELNAYVPVCSYTGPLTEDFLSSFQVVVLTNSPLEEQLRVGQFCHGHGIKLVVADTRGLFGQLFCDFGEEMILTDANGEQPLSAMVSMVTKDNPGVVTCLDEARHGFESGDFVTFTEVQGMSELNGISPMEIKVLGPYTFSICDTARFSDYIRGGIVTQVKVPKKISFKSLPVSLAEPEFVMTDFAKFSRPAHLHVAFQALHQFYSQRGRLPHPQNQLDAAEMVSLAQGIKEAASSGLLQEDLDEELVRQLAYMAAGDLAPINAFIGGLAAQEVMKACSGKFMPIMQWLYFDALECLPEDRETLTEDNCRPRQTRYDGQVAVFGSHLQEKLGKQRYFLVGAGAIGCELLKNFAMIGLGCGDSGEVIVTDMDTIEKSNLNRQFLFRPWDVTKLKSDTAAAAVRQMNPQIHVTSHQNRVGPDTERIYDDDFFQALDGVTNALDNVDARMYMDRRCVYYRKPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEKSIPICTLKNFPNAIEHTLQWARDEFEGLFKQPAESVNQYLTDPKFVERTLRLAGTQPLEVLEAVQRSLVLQRPRSWADCVAWACLHWHAQYANNIRQLLHNFPPEQLTSSGAPFWSGPKRCPHPLTFDVHNPLHLDYIMAAANLFAQTYGLVGSRDRAAVATLLQTVHIPEFTPKSGVKIHVSDQELQSANTSVDDSRLEELKATLPSPEKLSGFKMYPIDFEKDDDNNFHMDFIVAASNLRAENYDIPPADRHKSKLIAGKIIPAIATTTAAVVGLVCLELYKVVQGHQRLEAYKNGFLNLALPFFGFSEPIAAPRHKYYDHEWTLWDRFEVKGLHPGGEEMTLKQFLDYFKTEHKLEITMLSQGVSMLYSFFMPAAKLKERLDQPMTEIVSRVSKRKLGRHVQALVLELCCNDDSGEDVEVPYVRYAIR",
"proteome": "UP000002280",
"gene": "UBA1",
"go_terms": [
{
"identifier": "GO:0008641",
"name": "ubiquitin-like modifier activating enzyme activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0036211",
"name": "protein modification process",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"protein_evidence": 3,
"source_database": "unreviewed",
"is_fragment": false,
"in_alphafold": true,
"in_bfvd": false,
"ida_accession": "2ff4e9f5f1aa188276beeeaf98a83398464be63a",
"counters": {
"domain_architectures": 5363,
"entries": 35,
"isoforms": 0,
"proteomes": 1,
"sets": 3,
"structures": 0,
"taxa": 1,
"dbEntries": {
"cathgene3d": 6,
"cdd": 2,
"ssf": 1,
"pfam": 5,
"smart": 1,
"ncbifam": 1,
"panther": 1,
"prosite": 2,
"prints": 1,
"interpro": 15
},
"proteome": 1,
"taxonomy": 1,
"similar_proteins": 5363
}
}
}