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{
    "metadata": {
        "accession": "F7AW47",
        "id": "F7AW47_XENTR",
        "source_organism": {
            "taxId": "8364",
            "scientificName": "Xenopus tropicalis",
            "fullName": "Xenopus tropicalis (Western clawed frog)"
        },
        "name": "RUN and FYVE domain-containing protein 1",
        "description": [
            "Activating adapter involved in cargo sorting from early/recycling endosomes. Regulates retrieval of proteins from endosomes to the trans-Golgi network through interaction with the dynein-dynactin complex. Dual effector of RAB4B and RAB14, mediates a cooperative interaction allowing endosomal tethering and fusion. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking. In oocytes, self-assembles to form a protein matrix which hold together endolysosomes, autophagosomes and proteasomes and generate non-membrane-bound compartments called endo-lysosomal vesicular assemblies (ELVAs). In immature oocytes, ELVAs sequester ubiquitinated protein aggregates and degrade them upon oocyte maturation"
        ],
        "length": 599,
        "sequence": "MDERANLMNRMKLSIKVLIQSALNLGRCIDSEYPPLQQFFLVMEHCLKHGLKVKKTFMAQNKSFYGPLELVEKLCPESSDLFANIKNLPELKTAIGKGRAWLHLALMQKKLADYLQALIDHKDLLSDFYEQDALMMEEEGAVIVGLLVGLNMIDANLCLKGEDLDSQVGVIDFSFYLKDMQQNDNEKQSDEIVAVLDQKHYVEELNRHLSCTVGDLQAKIDSLEKTNSKLTEELLAAKDRIVSLQEEHNHILQESTLIREKSERSVEVNFQDTKVELDTYKQSRQGLDEMYNEIWKQLKVEKQARLELEKEFELQVGMKTEMEMAMKLMEKDIHEKQDTLVVLRKQLDDVKAINLQMCQKVLDAETALHKKNEIVNSVQAKGDQLTSALKQIEERLQKSEKTREAAEENCNKMKMEHGAKIGSLQQQLEKLNKTCAVLEKDLKSENEKHDTLQDKLHKEKETATSLRNELHQFSLLQKNFDNLHQEKKQLQRLCEEQEQALQEMGQHLSQSKLKMEDIKEVNKALKGHTWLKDDEATECKQCNKEFSISRRKHHCRNCGDIFCNSCSSNELSLPSYPKPVRVCDICHNLLLQRCSSNSS",
        "proteome": "UP000008143",
        "gene": "rufy1",
        "go_terms": [
            {
                "identifier": "GO:0046872",
                "name": "metal ion binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "9cd788d51d7d2f30e5de411ec424ca48dbca914c",
        "counters": {
            "domain_architectures": 5091,
            "entries": 22,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 3,
                "ssf": 3,
                "profile": 2,
                "smart": 2,
                "cdd": 1,
                "pfam": 2,
                "panther": 1,
                "interpro": 8
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 5091
        }
    }
}