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{
    "metadata": {
        "accession": "F7AVH2",
        "id": "F7AVH2_XENTR",
        "source_organism": {
            "taxId": "8364",
            "scientificName": "Xenopus tropicalis",
            "fullName": "Xenopus tropicalis (Western clawed frog)"
        },
        "name": "High affinity choline transporter 1",
        "description": [
            "High-affinity Na(+)-coupled choline transmembrane symporter. Functions as an electrogenic, voltage-dependent transporter with variable charge/choline stoichiometry. Choline uptake and choline-induced current is also Cl(-)-dependent where Cl(-) is likely a regulatory ion rather than cotransported ion. Plays a critical role in acetylcholine (ACh) synthesis by taking up the substrate choline from the synaptic cleft into the presynaptic nerve terminals after neurotransmitter release. SLC5A7/CHT1-mediated choline high-affinity transport in cholinergic neurons is the rate-limiting step for production of ACh, thereby facilitating communication by subsequent action potentials. Localized predominantly in presynaptic terminal intracellular organelles, and translocated to the plasma membrane in active form in response to neuronal activity"
        ],
        "length": 580,
        "sequence": "MAFHVEGLVAIILFYLAILFVGIWAAWRTKNSRGDGDPREGIIVGGRDIGLLVGAFTMTATWVGGGYINGTAEAVYVSDYGLAWAQAPIGYSLSLIVGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAILSALGATISVIVDIDINISVVVSALIATFYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFAMTHPAVTDITVTAVKEVYQKPWLGDIRAADAWNWLDSFLLLMLGGIPWQAYFQRVLSASSATYAQVLSFLAAFGCLVMAIPSVLIGAIGASTDWNQTSYEHDDPQMNEEADMILPIVLQYLCPPYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASEKEIVWVMRITVFIFGAAATAMALLAKSVYGLWYLSSDLVYIIIFPQLLCVLFIKGTNTYGSVAGYVFGALLRISGGEPYLHLQAFICYPGCYADKNDMYLQRFPFKTLSMVASFLANIAFSYLARYLFEKGILSPKFDFLNAVVAKHSEENMDKTTLVKSDNIVLSELAPVKPRQSLSLPSTFTNKEAISDLESSPESPDSENKEL",
        "proteome": "UP000008143",
        "gene": "slc5a7",
        "go_terms": [
            {
                "identifier": "GO:0022857",
                "name": "transmembrane transporter activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0055085",
                "name": "transmembrane transport",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0016020",
                "name": "membrane",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "2b2a6841043927bd4b57fafc3151ff36fdcbb775",
        "counters": {
            "domain_architectures": 98886,
            "entries": 8,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "profile": 1,
                "cdd": 1,
                "cathgene3d": 1,
                "panther": 1,
                "pfam": 1,
                "interpro": 3
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 98886
        }
    }
}