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InterPro-Version: 108.0
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{
    "metadata": {
        "accession": "E3TD94",
        "id": "E3TD94_ICTFU",
        "source_organism": {
            "taxId": "66913",
            "scientificName": "Ictalurus furcatus",
            "fullName": "Ictalurus furcatus (Blue catfish)"
        },
        "name": "Gamma-glutamylcyclotransferase",
        "description": [
            "Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos"
        ],
        "length": 204,
        "sequence": "MKPQDILTGKSNLWIFGYGSLVWKPDFKYKRSHVGFIRGYKRRFWHGDTFHRGSDEMPGRVVTLLEEDDECTWGVAFEVTGSQMEESLAYLNIREAVRGGYGTRMVDFIPRDEDQPSVQALVYIATEDNPNYLGPASTEEIAAQIAVCKGKTGYNVEYLLRLAEFMRQSCPGVDDSHLFSIEKACLSVFTPLLLASQKCAPSLN",
        "proteome": null,
        "gene": "CHAC1",
        "go_terms": [
            {
                "identifier": "GO:0061928",
                "name": "glutathione specific gamma-glutamylcyclotransferase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006751",
                "name": "glutathione catabolic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 2,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "d7339725ab49c2b7cf5d94f1d9bf486fc14c811e",
        "counters": {
            "domain_architectures": 12445,
            "entries": 8,
            "isoforms": 0,
            "proteomes": 0,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 1,
                "ssf": 1,
                "cdd": 1,
                "pfam": 1,
                "panther": 1,
                "interpro": 3
            },
            "proteome": 0,
            "taxonomy": 1,
            "similar_proteins": 12445
        }
    }
}