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{
    "metadata": {
        "accession": "E2BPS8",
        "id": "E2BPS8_HARSA",
        "source_organism": {
            "taxId": "610380",
            "scientificName": "Harpegnathos saltator",
            "fullName": "Harpegnathos saltator (Jerdon's jumping ant)"
        },
        "name": "DNA topoisomerase",
        "description": [
            "Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. Weakly relaxes negative supercoils and displays a distinct preference for binding single-stranded DNA",
            "Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand"
        ],
        "length": 851,
        "sequence": "MKTALMVAEKPSLAASLANILSNGRCVTRKGLNGTCPVHEWVDQFKYETVTFKMTSVCGHVMTLDFIGKYNNWDKVDPAELFSCPTEKKEALPKLKIPYILAKEGSHCDYLILWLDCDKEGENICFEVINAVQQGMHRKLHPNDIWRARFSAITEKDIKSALENLIKPNENEAKSVDARQELDLRIGCAFTRYQTKFFQGKYGDLDVSLISYGPCQTPTLGFCVQRHDEIQTFKPDPYWVLQVTIKCADGQDIILNWSRVRSFDKEVANMFLSHVKEYERATVVSIQSTEKSKSRPIALNTVELMRVASSGLGMGPQHAMQIAERLYTQGYISYPRTETTSYPENFDLLSTLKQQQNNPEWGEDVRKILAAGINRPKKGHDAGDHPPITPMKHATRNELDGDSWRLYDYITRHFIATLARDCKYLSTTVKFEIGMEIFTATGHSLLDAGYTSILTWQALGSSDTLPKFTAEEKVNIQEAKLLECYTQPPDYLTEAELISLMEKHGIGTDASIPVHINNICIRNYVNVTVGRRLVPTSLGIVLVHGYQKIDPELVLPTMRSAVEEQLNLIALGRADFHAVLQHTVEIFKQKFHYFVQSIEAMDQLFEVSFSPLSASGKAHSRCGKCRRYMKYIQTKPSRMHCAHCNETYNLPQNGNIRIYKELKCPLDDFELLSWSTGARGKSYTFCPYCYNNPPFRDMKKGMSGCNSCTHPTCPHGMNSTGLSSCLECDLGILVLDPSAAPKWKLGCNRCDVIIHLFENAHKVTVDTDVCDCGAQLVTVEYKQDKSKLPNEATEMSGCVFCTSAFAPLVEKHRAVASKPVVTRGRGHTKSRNRGKPKPPKDKMAQLAAYFV",
        "proteome": "UP000008237",
        "gene": "EAI_09253",
        "go_terms": [
            {
                "identifier": "GO:0003677",
                "name": "DNA binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0003916",
                "name": "DNA topoisomerase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006265",
                "name": "DNA topological change",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0003917",
                "name": "DNA topoisomerase type I (single strand cut, ATP-independent) activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "dc5193b5326871adfb5f4943aa19584fbef17597",
        "counters": {
            "domain_architectures": 2089,
            "entries": 30,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 4,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 4,
                "smart": 3,
                "profile": 2,
                "cdd": 2,
                "ssf": 1,
                "pfam": 3,
                "panther": 1,
                "prints": 1,
                "prosite": 1,
                "interpro": 12
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 2089
        }
    }
}