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{
    "metadata": {
        "accession": "A6LBE0",
        "id": "A6LBE0_PARD8",
        "source_organism": {
            "taxId": "435591",
            "scientificName": "Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)",
            "fullName": "Parabacteroides distasonis (strain ATCC 8503 / DSM 20701 / CIP 104284 / JCM 5825 / NCTC 11152)"
        },
        "name": "Endonuclease MutS2",
        "description": [
            "Acts as a ribosome collision sensor, splitting the ribosome into its 2 subunits. Detects stalled/collided 70S ribosomes which it binds and splits by an ATP-hydrolysis driven conformational change. Acts upstream of the ribosome quality control system (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes and their subsequent degradation. Probably generates substrates for RQC",
            "Endonuclease that is involved in the suppression of homologous recombination and thus may have a key role in the control of bacterial genetic diversity"
        ],
        "length": 822,
        "sequence": "MIYPQNFEQKTGFDKIRHLITEKCLSPLGEERVAEMGFSADFEVVSKRLEQTDEFIRILHGDTEFPASYFFDVRYSLKRIRPEGTWLDERELFDLKRSLQTINDIVRFFKPMDDEEIKYPALTELAGDIFVFPQLIGKIDSILDKFGKVKDSASSTLSQIRREMTITMSGISRSLQSILRAAQSDGVVDKDVTPTMRDGRLMIPVAPAFKRKIKGIVHDESASGKTVFIEPEVVVEANNRIRELEGEERREIIKILTEFTNVIRPLAPDILQSYEFLADIDFIRAKALFAEQVKAIKPIVEDKRQMDWVRAVHPLLFLSLQKQGKQVVPLDIELTEGKRILIISGPNAGGKSVCLKTVGLLQYMLQCGLLIPLHERSRTGIFEHIFIDIGDEQSIENDLSTYSSHLTNMKYFVKNCNERTIILIDEFGSGTEPQIGGAIAEALLDRFNRNHSFGVITTHYQNLKHFAEDTEGIVNGAMLYDRHLMQPLFKLSIGNPGSSFAVEIARKIGLPEDVIADASANVGADYINMDKYLQDIVRDKRYWESKRQNIRQQEKKLEDVTSRYEQDLEAVNKQRKEIIREAKAEAQRILAEANAKIENTVREIKEAQAEKEQTKLARKALEEFKNSVMATEEEDDKIARKMAKLKERNERKKQKQKVTAQPIFNKEVIEVGDNVRLKGQVSAGTVMELQGKQAVVAFGMIKSTVKLEQLEKVSKGQIKREIQKSTFVSSQTTDNMHEKKINFKQEIDVRGMRGDEALQSVTYFIDDAIQVGAGKVRILHGTGTGILRQLIRDYLRTVPGVRRFQDEHVQFGGAGITVVEFD",
        "proteome": "UP000000566",
        "gene": "mutS2",
        "go_terms": [
            {
                "identifier": "GO:0005524",
                "name": "ATP binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0030983",
                "name": "mismatched DNA binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006298",
                "name": "mismatch repair",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0004519",
                "name": "endonuclease activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0016887",
                "name": "ATP hydrolysis activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0045910",
                "name": "negative regulation of DNA recombination",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0140664",
                "name": "ATP-dependent DNA damage sensor activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "3e4b5aa629de76a19fdee936f19ea82a5ec69f0f",
        "counters": {
            "domain_architectures": 7334,
            "entries": 27,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "smart": 3,
                "ssf": 3,
                "cathgene3d": 2,
                "pfam": 3,
                "cdd": 1,
                "profile": 1,
                "hamap": 1,
                "ncbifam": 1,
                "pirsf": 1,
                "panther": 1,
                "prosite": 1,
                "interpro": 9
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 7334
        }
    }
}