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{
"metadata": {
"accession": "A4IIS8",
"id": "S47A1_XENTR",
"source_organism": {
"taxId": "8364",
"scientificName": "Xenopus tropicalis",
"fullName": "Xenopus tropicalis (Western clawed frog)"
},
"name": "Multidrug and toxin extrusion protein 1",
"description": [
"Multidrug efflux pump that functions as a H(+)/organic cation antiporter. Mediates the secretion of cationic compounds including drugs, toxins and endogenous metabolites. Plays a role physiological role in the excretion of drugs, toxins and endogenous metabolites through the kidney and liver, into urine and bile respectively"
],
"length": 574,
"sequence": "MEGQAAETNHRAETVVRAELCLSAEQGPETTAYSQKRCLFLPMEVWQEAQQLLALAAPAFLSQLMIFLISIVSSIFCGHLGKVELDAVSLAITIINITGVAVGTGLAGACDTLISQTFGGSNLKLVGIILQRGILILLLFCFPCWALLINTESILLLFRQDPEVSKLTQIYVLIFLPALPAAFLYQLLAKYLQNQGIIYPQVLTGFIANIFNALFNYILLYVLGLGVMGSACANTVSQFIQMILLFLYIVWRRLYADTWGGWSQACFEEWGAFIRLAVASMLMLCIEWWAFEISMFLAGVLGMVDLAAQAIIYQVAIVVYLIPLGLCIAGSIRVGHGLGAGNTEQAKRSALVVLCMTELCALLSGILLATLKDVVAYIFTSDPNIVALVSYVLPVYSACLLFDACVAACGGILRGSGKLKVGAISHTVGYYVIGLPLGISLMFAAKLGIIGFWFGILACGIAQSIFLIIFVFKIDWKRASEEAQTRASERVEIPQKIDNKPSVYQEGCPTEQGDVDPGNVESIEFSQSSTSSEGTSPTPAGAAQHTRTLILTRGLALGCAVGTLIIGIVIRLSV",
"proteome": "UP000008143",
"gene": "slc47a1",
"go_terms": [
{
"identifier": "GO:0042910",
"name": "xenobiotic transmembrane transporter activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:1990961",
"name": "xenobiotic detoxification by transmembrane export across the plasma membrane",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0015297",
"name": "antiporter activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0055085",
"name": "transmembrane transport",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0016020",
"name": "membrane",
"category": {
"code": "C",
"name": "cellular_component"
}
}
],
"protein_evidence": 2,
"source_database": "reviewed",
"is_fragment": false,
"in_alphafold": true,
"in_bfvd": false,
"ida_accession": "09871bc0b80832b4d6c518e1674c7713751cbd0a",
"counters": {
"domain_architectures": 121512,
"entries": 6,
"isoforms": 0,
"proteomes": 1,
"sets": 2,
"structures": 0,
"taxa": 1,
"dbEntries": {
"cdd": 1,
"panther": 1,
"pfam": 1,
"ncbifam": 1,
"interpro": 2
},
"proteome": 1,
"taxonomy": 1,
"similar_proteins": 121512
}
}
}