HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept
{
"metadata": {
"accession": "A0JM37",
"id": "A0JM37_XENTR",
"source_organism": {
"taxId": "8364",
"scientificName": "Xenopus tropicalis",
"fullName": "Xenopus tropicalis (Western clawed frog)"
},
"name": "Hedgehog protein",
"description": [
"The C-terminal part of the desert hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein into two parts (DhhN and DhhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated DhhN. Both activities occur in the endoplasmic reticulum",
"The dually lipidated desert hedgehog protein N-product (DhhNp) is essential for a variety of patterning events during development. Involved in the early induction and patterning of anterodorsal ectoderm, nervous system and somites. Induces ectopic cement gland formation in embryos. Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes",
"[Protein hedgehog N-product]: The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development",
"[Protein hedgehog]: The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product"
],
"length": 396,
"sequence": "MPAVRILTLAVCCWLLLVPVCCCGPGRGPVGRRRYMRKLVPLRYKQFVPNVPEKTLGASGKSEGKIRRGSERFIELVPNYNPDIIFKDEENTGADRLMTERCKDRVNALAISVMNMWPGVKLRVTEGWDEDGHHAHDSLHYEGRALDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHVSVKADNSLGVRSGGCFPGTAMVMMASGEKKSLSELQLGDTVFTTDETGQLIPSVVLLFLHRDLYKTATFVLIEAEGHTSKLLVTPNHLLFIKRSLSAGFLPTFAYRVQIGDLVQIYVNGTQLQPSKVVRVSVEEQTGVYAPMTEHGTLLVDGVLTSCYATVESHTLAHASLAPLRLFKGIASMLPDLDLSDGVHWYCHILYLLAKYVLWWDMP",
"proteome": "UP000008143",
"gene": "dhh",
"go_terms": [
{
"identifier": "GO:0007267",
"name": "cell-cell signaling",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0016540",
"name": "protein autoprocessing",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0016539",
"name": "intein-mediated protein splicing",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0007275",
"name": "multicellular organism development",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"protein_evidence": 2,
"source_database": "unreviewed",
"is_fragment": false,
"in_alphafold": true,
"in_bfvd": false,
"ida_accession": "a73b552ecc23d61627e97e1396c48fbde1a4af23",
"counters": {
"domain_architectures": 2934,
"entries": 22,
"isoforms": 0,
"proteomes": 1,
"sets": 3,
"structures": 0,
"taxa": 1,
"dbEntries": {
"cathgene3d": 2,
"pfam": 2,
"ssf": 2,
"smart": 2,
"profile": 1,
"cdd": 1,
"pirsf": 1,
"panther": 1,
"prints": 1,
"interpro": 9
},
"proteome": 1,
"taxonomy": 1,
"similar_proteins": 2934
}
}
}
