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{
    "metadata": {
        "accession": "A0A9L0RW12",
        "id": "A0A9L0RW12_HORSE",
        "source_organism": {
            "taxId": "9796",
            "scientificName": "Equus caballus",
            "fullName": "Equus caballus (Horse)"
        },
        "name": "Histone-lysine N-methyltransferase 2D",
        "description": [
            "Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription"
        ],
        "length": 5528,
        "sequence": "MDSQKPPGEDKDSESAADGPAASEESGATEPDLPNPHVGEVSVPSSGGPRVQEPLQDCSGGPPRRCALCNCGEPSLHGQRELRRFELPFDWPRCPVVSPGGNPGPSEAALPSEDLSQIGFPEGLTPAHLGEPGGSCWAHHWCAAWSAGVWGQEGPELCGVDKAIFSGISQRCSHCTRLGASIPCRSPGCPRLYHFPCATASGSFLSMKTLQLLCPEHSEGAAHLEEARCAVCEGPGELCDLFFCTSCGHHYHGACLDTALTARKRAGWQCPECKVCQACRKPGNDSKMLVCETCDKGYHTFCLKPPMEELPAHSWKCKACRVCRACGASSAELNPNSEWFENYSLCHRCHKAQGGQPISSVAEQHPPVCSRFLPPEPGDTPTDEPDALYVACHGQPKGGHVTSMQPKEPGPLQCEAKPLGRAGAQLEPQLEAPLNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEESPLSPPPEESPLSPPPESSPFSPLEESPFSPPQESPPSPPLETPLSPPPETSPLSPPLEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEDSPMSPPPEASRLSPPPEDSPTSPPPEDSPASPPPEDLLMSLPLEESPLSPLSEEPQLCPRPEELRLSPGSEGRHLSPASEGPCLSPRPEEPRLSPRPEEPCLSPRPEEPRLSPRPEEPCLSPAPEELHLSPQPEEPPLSPQREELHPSPQPEEPPLSPRPEELRLSPHPEELRLSPHPEELRLSPHPEELRLSPHPEELRLSPRPEETHLSPQPEEPCLSPRPEEHPEQPGLCPAPEELPLFLPPGEPPLSPLLGEPALSEPGEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITAVAPPALSPLGELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPMILPPSPGSPMGLASPVLMEPLPPQCSPLLQDSLPPQNSLPSQCSPALPLSLPSPLSPMEKAVEVSEEAEPHEMETEKVPEPECPALEPSPTSPLSSPMGNLSCPAPSPAPALDDFSGLGEDIAPLDGTDTPGSQPEAGQTPGSLASELKGSPVLLDPEELAPVTPMEVYGPECKQAGQGSPCEEQEEPRAPVAPTPPTLIKSDIVNEISNLSQGDASASFPGSEPLLGSPDPEGGGSLSMELGVSTDVSPARDEGSLRLCTDSLPETDDSLLCDAGTAIGGGKAEGDKGRRRSSPARSRIKQGRSSSFPGRRRPRGGAHGGRGRGRARLKSTTSSVETLVVADIDSSPSKEEEDDDDDTMQNTVVLFSNTDKFVLMQDMCVVCGSFGRGAEGHLLACSQCSQCYHPYCVNSKITKVMLLKGWRCVECIVCEVCGQASDPSRLLLCDDCDISYHTYCLDPPLLTVPKGGWKCKWCVSCMQCGAASPGFHCEWQNSYTHCGPCASLVTCPICHAPYVEEDLLIQCRHCERWMHAGCESLFTEDDVEQAADEGFDCVSCQPYVVKPAAPVAPPELVPMKVKEPEPQYFRFEGVWLTETGMAVLRNLTMSPLHKRRQRRGRLGLPGEAGLEGSEPSDALGPDDKKDGDLDTDELLKGEGAVEHMECEIKLEGPISPDGEPGKEETEESKKRKRKPYRPGIGGFMVRQRKSHTRVKKGPAAQAEVLSGDGQPDEGETVMPADLPAEGSVDQSLADGDEKKKQQRRGRKKSKLEDMFPAYLQEAFFGKELLDLSRKALFAVGVGRPSFALGTPKAKGDGGSDKKELPTSQKGDDGPDVADEESRGPEGKPDTPGPEDGGVKASPVPSDPEKPGTPGEGMLSSDLDRIPTEELPKMESKDVQQLFKDVLGSEREQHLGCGTPGLDGSRTPLQRPFLQGGLSLGNLPSSSPMDSYPGLCQSPFLDSRERGGFFSPEPGEPDSPWTGSGGTTPSTPTTPTTEGEGDGLSYNQRSLQRWEKDEELGQLSTISPVLYANMNFPNLKQDYPDWSSRCKQIMKLWRKVPAADKAPYLQKAKDNRAAHRINKVQKQAESQINKQTKVGDMARKTDRPALHLRIPPQPGALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAGTVPGPDSPGELFLKLPPQVPAQVPSQDPFGLAPTYALDPRFPTAPPTYPPYPSPTGAPAQPSTLGASSRPGTGQPGEFHTTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPGVGGGKASEPLLSPPPFGETRKALEVKKEELGASSPSYGPPNLGFVDSPSSGPHLGGLELKAPDVFKAPLTPRASQVEPQSPGLGLRPQEPAPAQALAPSPPSHSDIFRPGPYPDPYAQPPLTPRPQPPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPDPYSRPPSRPQSRDPFAPLHKPPRPQPPEVAFKAGPLAHTPLGAGGFPAALPSGPAGELHAKVPGGQPPNFARSPGTGAFVGTPSSMRFTFPQAVGEPSLKPPVPQPGLPPPHGINSHFGPGPTLGKPQSTNFTVATGNFHPSGSPLGPSTGSTGEGYGLSPLRPPSVLPPSAPDGSLPYLSHGASQRAGITSPVDKREDPGAGMGSSLAAPELPGTQDPGMSSLSQTELEKQRQRQRLRELLIRQQIQRNTLRQEKETAAAAAGAVGTPGSWGAEPSSPAFEQLSRGQTPFTGTQDKNSLVGLPPGKLGGPILGPGAFPSDDRLSRPPPPATPSSMDVNSRQLVGGSQAFYQRAPYPGSLPLQQQQQQQLWQQQQQQQQATAATSMRLAMSARFPSAPGPELGRQALGSPLAGIPTRLPGPGEPLPGPAGPAQFIELRHNVQKGLGPGGAPFPGQGPPQRPRFYPVNEDSHRLPPEGLRGLAVSGLPPQKPSAPPAPELNNSLHPTPHTKVPTLPPGLELVSRPPSSSELGRPPPLALEAGKLSCEDPELDDDFDAHKALEDDEELAHLGLGVDVAKGDDELGTLENLETNDPHLDDLLNGDEFDLLAYTDPELDTGDKKDIFNEHLRLVESANEKAEREALLRGVEPGPLGPEERPPPAADASETRLASVLPEVKPKVEEGGRHPSPCQFTITTPKVEPAPATPSLGLGLKPGQSVMGSRDTRMGTGPFSSSGHTTEKGPFGATGGPPSHLLTPSPLSGPGGSSLLEKFELESGTLTLPGGHAASGDELDKMESSLVASELPLLIEDLLEHEKKELQKKQQLSAQLQPAQQQQQQQQQQQQHSLLATPGPTQAMSLPHEGSSPSLAAPQQQLALGLGGSRQPGLAQPLMPTQPPAHALQQRLAPSMTMVSNQGHMLSGQHGGQAGLVPQQSPQPVLTQKPMSTMPPSMCMKPQQLAMQQQLANSFFPDTDLDKFAAEDIIDPIAKAKMVALKGIKKVMAQGSIGVAPGMNRQQVSLLAQRLSGGPGSDLQNHVAAGSGQERSAGDPSQPRPNPPTFAQGVINEADQRQYEEWLFHTQQLLQMQLKVLEEQIGVHRKSRKALCAKQRTAKKAGREFPEADAEKLKLVTEQQSKIQKQLDQVRKQQKEHTNLMAEYRNKQQQQQQQQQQQQHSAVLALSPSQSPRLLTKLPGQLLPGHGLQPPQGPPGGQAGGLRLPPGGMALPGQPGGPFLNTTLAQQQQQQHSGGAGALAGPSGGFFPGNLALRGLGPDSRLLQERQLQLQQQRMQLAQKLQQQQQQQQQQQQHLLGQVAIQQQQQQGPGVQANPALGPKPQGLLPPSSHQGLLVQQLSPQPPQGPQGMLGPAQVAVLQQQQQQQQQQHHPGVLGPQGPHRQVLLNQSRVLSSPQLAQQGQGLTGHRLVTAQQQQQQHQQQGSVAGLSHLQQGLMPHSGQPKLSAQPMGSLQQQQLQQQQLQQQQQQLQQQQQQLQQQQQQLQQQQQQQQQQQQQQLQQQQLQQQQFQQQQQQQMGLLNQSRTLLSPQQQQQQQQQQQQQVTLGPGMPAKPLQRFSSPGALGPTLLLTGKEQSIVETALPPEATEGPSTHQGGPLAVATVPESVATEPGEVKPSLSGDAPLLLVQPQAQPQPNSVQLQPPLRLPGQQQQQVNLLHTAGAGSHGQPTSGSSSEASPLPHLLAQSSVSLGEQPGPMTQNLPGSQQPLGLERPMQNNAGSQPAKPGSAPQSGQGLPGTGLMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQAVRQTPPYQDPGTQPSPLQGLLGRQPHLGGFPGSQTGPLQELGAGLRPQGAPRLPTPQGALSTGPVLGPVHPTPTPSSPQEPKRPSSQLPSPSSQLPSEAQLTPIQPGTPKPQGPPLELPPGKVSPASAQLADAFFGKGVGPWDPPDNLAEAHKPEQSSLVPGHLEQVNGQVAPEPPHLSIKQEPREEPCALGTQAVKREANGEPIGAPGTSNHLLLAGPRSEAGHLLLQKLLRAKNVQLSTGQGPEGLRAEINGHIDSKLAGLEQKLQGTTSNKEDTAARKPLTPKPKRVQKASDRLVSSRKKLRKEDGVRASEALLKQLKQELSLLPLTEPTITANFSLFAPFGSGCPINGQCQLRGAFGSGALPTGPDYYSQLLTKNNLSNPPTPPSSLPPTPPPSVQQKMVNGVTASEELGEHPKDAASARDTEGTLRDASEVKSLDLLAALPTPPHNQTEDVRMESDEDSDSPDSIVPASSPESILGEEAPRFPQLGSGRWEQDDRALSPVIPIIPRASIPVFPDTKPYGSLDLEAPGKLPATTWEKGKGSEVSVMLTVSAAAAKNLNGVMVAVAELLSMKIPNNYEVLLPESPARAGIEPKKGEAEGPGGKDKGLGGKSPEAGPDWLKQFDAVLPGYTLKSQLDILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPPSPLAPSPASPATEPLVELPAEPSAEPPVPSPLPLASSPESARPKPRARPSEEGEDSRTPRLKKWKGVRWKRLRLLLTIQKGSGRQEDEREVAEFMEQLGTALRPDKVPRDMRRCCFCHEEGDGATDGPARLLNLDLDLWVHLNCALWSTEVYETQGGALMNVEVALHRGLLTKCSLCQRTGATSSCNRMRCPNVYHFACAIRAKCMFFKDKTMLCPMHKIKGPCEQELSSFAVFRRVYIERDEVKQIASIIQRGERLHMFRVGGLVFHAIGQLLPHQMADFHSATALYPVGYEATRIYWSLRTNNRRCCYRCSIGENNGRPEFVIKVIEQGLEDLVFTDASPQAVWNRIIEPVAAMRKEADMLRLFPKYLKGEELFGLTVHAVLRIAESLPGVESCQNYLFRYGRHPLMELPLMINPTGCARSEPKILTHYKRPHTLNSTSMSKAYQSTFTGETNTPYSKQFVHSKSSQYRRLRTEWKNNVYLARSRIQGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQNRGIYMFRINNEHVIDATLTGGPARYINHSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQFDFEDDQHKIPCHCGAWNCRKWMN",
        "proteome": "UP000002281",
        "gene": "KMT2D",
        "go_terms": [
            {
                "identifier": "GO:0005634",
                "name": "nucleus",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            },
            {
                "identifier": "GO:0042800",
                "name": "histone H3K4 methyltransferase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0035097",
                "name": "histone methyltransferase complex",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            },
            {
                "identifier": "GO:0005515",
                "name": "protein binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": false,
        "in_bfvd": false,
        "ida_accession": "5bda398aba0763c87ec8139d84177767c0d96f3d",
        "counters": {
            "domain_architectures": 1551,
            "entries": 54,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 5,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "profile": 7,
                "cathgene3d": 4,
                "cdd": 8,
                "pfam": 6,
                "smart": 7,
                "ssf": 3,
                "panther": 1,
                "interpro": 18
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 1551
        }
    }
}