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{
    "metadata": {
        "accession": "A0A9E3H6E4",
        "id": "A0A9E3H6E4_9NOST",
        "source_organism": {
            "taxId": "1117104",
            "scientificName": "Pelatocladus maniniholoensis HA4357-MV3",
            "fullName": "Pelatocladus maniniholoensis HA4357-MV3"
        },
        "name": "(S)-8-amino-7-oxononanoate synthase BioU",
        "description": [
            "A 'suicide' enzyme that participates in biotin synthesis. Catalyzes the formation of (S)-8-amino-7-oxononanoate (DAN-carbamic acid) from (7R,8S)-8-amino-7-(carboxyamino)nonanoate (DAN), a function equivalent to the cannonical BioA reaction and the first half-reaction of BioD. The cellular requirement for biotin is thought be low enough that this single turnover enzyme supplies a sufficient amount of the cofactor. Overall it catalyzes three reactions: formation of a covalent linkage with 8-amino-7-oxononanoate to yield a BioU-DAN conjugate at the epsilon-amino group of Lys124 of BioU using NAD(P)H, carboxylation of the conjugate to form BioU-DAN-carbamic acid, and release of DAN-carbamic acid using NAD(P)+"
        ],
        "length": 340,
        "sequence": "MHTEQIIGSTNFAQAIRIGVLGFGGLGQAAAKVLAQKQEMILVAAADNKGYAYATEGLNAEKCITTYQSQGSLGYLEPFGTLTNQSIQDLIESNQPVDGYFLALPNLPNDFIATVTKQFIDSGWRGVLVDAIKRTSAVEQLLTLKEELQTAGITYMTGCGATPGLLTAAAAIAAQSYAEIHRVEITFGVGIANWEAYRATIREDIAHMPGYNVETARAMTDAEVEALLDKTNGVLTLENMEHADDVMLELAGICARDRVTVGGVVDTRNPKKPLSTNVKITGRTFEGKISTHTFTLGDETSMAANVCGPAFGYLKAGINLHQRGIHGIFTAAEIMPQFVR",
        "proteome": null,
        "gene": "bioU",
        "go_terms": [
            {
                "identifier": "GO:0016491",
                "name": "oxidoreductase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006520",
                "name": "amino acid metabolic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0008483",
                "name": "transaminase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0009102",
                "name": "biotin biosynthetic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "37b55cef7cd5294892fca7ec7bd212a823231420",
        "counters": {
            "domain_architectures": 3372,
            "entries": 8,
            "isoforms": 0,
            "proteomes": 0,
            "sets": 1,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 1,
                "pfam": 1,
                "ssf": 1,
                "hamap": 1,
                "ncbifam": 1,
                "interpro": 3
            },
            "proteome": 0,
            "taxonomy": 1,
            "similar_proteins": 3372
        }
    }
}