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{
"metadata": {
"accession": "A0A8V5GRP9",
"id": "A0A8V5GRP9_MELUD",
"source_organism": {
"taxId": "13146",
"scientificName": "Melopsittacus undulatus",
"fullName": "Melopsittacus undulatus (Budgerigar)"
},
"name": "Ryanodine receptor 1",
"description": [
"Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis"
],
"length": 4685,
"sequence": "ASKQRSEGEKVRVGDDLILVSVSSERYLHLSTASGELQVDASFMQTLWNMNPISSGGEEGYVTGGHVLRLFHGHMDECLTAAAPEQGEERSVVSYEGGAVCSQARSLWRLEPLRISWSGSHVRWAQPFRLRHVTTGRYLGLQGEQGLMLLEASAANTHVTAFCFRASKEKSEPVPRRDIEGMGPPELKYGESLCFLQHLDSGLWLTYAAADPKALRLGLLKRKAILHQEGHMDDSLSLSRSQAQEAQAARMVFSTAGLYGSFIRSLDALGSRPRSGPAPPALPLAAVELSLRDLIRYFRCPRGAELHEQRQRALRMLRARQNLFQQEGLVSLLLTCIDRLSGLSSALAERGGGEEAAAAKEVVNLLYELLASLIRGNRSNCALFCSNLDWLVGKLDRLEASSGILEVLYCVLIESPEVLNIIRENHIKSIIALLDKHGRNHKVLDVLCSLCVCDAVAVRSNQNLITENLLPRRDLLLQTGLVDRVTSIRPNVFVGTHAGSTQYPRWYYEVVLESLGCAIGTHSGVPRSVPAPQRRALTGGDVISCCLDLGVPSASFRLNGAPVHGMLEAFNLDVLYSPVVTCSAGVRLRLLLGGRQGQFRFLPPPGYSPVAQALLPRERLRLEPCKEHEGRGGPPGSRSLLGPPLPLPHTAFTPCPVDTAQIVLPPHLERVREKLAENIHELWALTRIEQGWSYGPVRDDAQRLHPCLLSFHNLPDPERSYNLQMSGETLKTLLALGCHVGMADEKAEENLRKIKLPKTYTMSNGYKPAPLDLAHVKLTPAQLTLVDRLAENSHNVWARDRVQQGWSYSTVQDIKDKRNPRLVPYNLLDENTKSRNRESLGQAVRTLLGYGYNIEPPDQDTPPGPPGVRPRLFRAERSLAVSSGRWYFEFEAVTGGPMRVGWARPHLRPDIDLGADELAFAFDGHRAQRWHVGSESFGRPWQAGDVVGCMIDLTETHISFTLNGEMLISDAGSEVAFKGFDVGEGFVPACSLPPGHWGRLNLGSVVSSLRFFTVCGLQEGFEPFGVNRKRPLPLWVSHSCPRFLPLPPEHPHIEVTRVDATPDSPPSLRLSRRAPAATPPSGAELVQLRLSLPVRFHARFRCAPPMPPGPAPPAPPPDPGTTPTAQPLPPGAPPPEAPRGGGGENEKDAATEKGKTRRGFLFKGRKVPFSPPPTAPSVPRLEQDVVPAERDDPDVIRDSTTHYFSVRLPAGQDPSCAWVGWVTPGFQQHEVTFDLSRVRSVTVTLGDSQGHVHRSIKHSDCYMVWGGDLVIGQPNRVSHTDLVIGCLVDLATGLLSFMVNGTEISTFFQVEPNTKLFPAAFVVPTSQNFLQFELGKLKNILPLSAALFSSEQGNPETMDILELWEDPSLQRFQHHTLRLYRAVCALGNTRVAHALCSHVDQAQLLFSIACTELPGPLRCGYYDLLLAMHLDAPRRAMSAMSAEFIVPVTDDAARVALSAGGTRVPGVARGVCLRPRPRFAEPCFILAPGNGHNQLSPWIPLGELGARAIGMLAEAVEGAGPSVRDPIGGSVEFELVPVLKLVSALLELGALEDEEVRKVLRMIEPRVFGEGKEEEEEEEERRRKAIEAGEEEEEEEEKEEEEKEEEEEKEKGEEEEKEEDEGPQEGLLQMKLPESVKLQMCELLQFFCSRELQHRVESLVWFAAQHVQRLQRDQRRRYQRLMQALTMSAAETARRTREFRSPPQEQVNMLLHYKDGLDEEECPVPEDIRDELQEFHNNLLAHCGIQLPQEEEEEEEDASLGQRLLGLVHRVLGRGGGHKEEEQPPPPPRGTLISQTMVHWAQESFIQSPELVRSMFSLLHRQYDALGELVRALPRAYALSARSVPDAIALLESLSQIRSLLIVQMGPEEEDLLIQSIGNIMNNKVFYQHPNLMRALGMHETVMQVMVSVLGGGESKEIRFPKMVTSCCRFLCYFCRISRQNQRSMFDHLGYLLENSSIGLGMRGSTPLDVAAASVIDNNELALALKEQDLEKVVSYLAGCGLQSCPMLLAKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVVRLLIRRPECFGPALRGEGGAGLLAAIEEAMGTAQDPARDGPSGRRERRRELFGPEEPPEEGRVHLGNAIMSFYAALIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPLEDLVGIISLPLQLPCIGKDGSVLEPRLAAGFAPEHKAPMVLFLDRVYGVSSQELLLRVLDVGFLPDLRAAASLDTATFSTTEMALALNRYLCQAVLPLLTKCARLFAGSQHRAGLVDSALHTVYRLSRARALTKAQRDTIDEGLMALCRYIHPSMLQHLLRRLVFDVPILNEFSKMPLKLLTNHYERCWKYYCLPSGWPNHGVSSEEELHLTRKLFWGIFQSLAHKRFDPELSRLAMPCLCAIAGALPPDYADASYSSRTDKKAAVDAEGNFDPKPVETLNVIIPEKLDSFINKYAEFTHEKWAFEKVQSNWTFGETVDEEAKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMLAWEWTVEKAREEEEKVEKKKSRKISQSAQATYDPSHGYSPQPVDLSGVTLSRELQAMAEQLAENYHNTWGRKKKLELEAKGGGSHPLLVPYDTLTAQEKARDREKAQELLKFLQLQGYAVTRGLKDLELDTSSIEKRFAFGFLQQLLKWMDTSQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKVLLPLINRYFHNHCGYFLSTPALALGTGGHASNKEKEMVTSLFCKLAALVRHRVSLFGTDAPAVVNCLHILARSLDARTVMKSGPEIVKAGLRSFFEGAAEDMEKLVENLRLGKVSGGKRQVKGVAQNLSYTGAALLPVLSSLFQHLGQLRCGDDVILDDVQVSCYRILSSIYSLGTTKNPYVERQRPALGECLARLAAAMPVAFLEPHLNHLNPCSVYSTKSARERAGERRSRAAPSPLVLGLPSRVQDLCPDLPSLDHLMGDIGALAESGARYTEMPHVIEVTLPMLCSYLPRWWERGPEARPEGPCATAVTGAHLNTLLGNILRIVVNNLVFAQPIVSKAKPQLLRSHFIPTMEKLKKRAGKVVAEEEQLRMEARGEGEETELLIRDEFSVLCRDLYALYPLLIRYVDNSRAQWLTEPNEDAEELFRMVGEVFIYWSKSHNFKREEQNFVVQNEINNMSFLTADSKSKMAKGGSAPERSQAPRRGDRYSVHTSLIVATLKKLLPIGLNLCSPADQELIALAKGRYAMKDTDEEVREFLTNNLHLQGKGQNSASLRWQMMLFRSLAGRAADAQSPERVVRRVQEVAAVLYHLEQTEHSYKSKRAVWHKLLSKQRRRAVVACFRMAPLYNLPRHRACNLFLEAYRLQWLQPQEHPFEDRMIDDLAASGQEEEEEEEEEEKKPDPLHQLILHFSRTALTEGSKLESDHLYMAYAGIMAKSCHIEEEEEEEEEEQEEEEAEDSFEEKELEKQKLRYQQGRLHERGAAEMVLQMLSACKGERGSMVSSTLKLGISILNGGNAEVQQKMLDYLKEKREVGFFQSLQALMQTCSVLDLNAFERQNKAMGLGMVAEDGTISRDNGEKVMADDEFTQDLFRLLQLLCEGHNNDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKEVIDEHGKRNFSKAMAVAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVIGFLHVFAHMMKKLAQHSSQIGLLKELLDLQKDMVVMLLSLLEGNVVNGTIARQMVDMLVESSSNVTMILKFFDTFLKLRDIVSSDAFRASITDPRGLMSKKDFQRAMDNQKQLEPSEIQFLLSCSEADENDMIDVDSFACRFQEPARDIGFNVAVLLTNLSEHVPHDQRLHTFLEHASSILEYFRPFLGRIEVMGSARRIERLYFEISAANKAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTIFEMQIASRLSEDGTAAPETDDGSDDGDDDGGEASAEARPRWSRVLALCRRRLRQWRRRPCRELARAAGGGLGRALWGAAGAGCGAVSAMGRVLWGAVFGGGLVEGAQRLALAEVLAGMPDPTQDAVGGAAVGGEGEDGGGPIEELGPIEEAQEEKEEEEEEEEEEEGKGKAMPLVPLGGQKEHPRLAALEATVGGLGDIGEPPGAEPPTPEGSPILRRKGGVCVGHTENGEKGGAEGGPDPVPPKRRRSVPKARKEPPSDGAFEVWGELEVQRVKFLNYLSRNFYNLRFLALFLAFAINFILLFYRVSEHPPGTEEGEEGSGGGAMAEEGAEPEEAPPIHYVLEEGTGYMQPALRALALAHTLVAFLCIIGYNCLKIPLVIFKREKELARSLEFSGLYISEQPPDDDVKGQWDRLVLNAQSFPRNYWDKFVKRKVLDKYGAIYGRERIAELLGMDLDSLEIGARGERRPPPDSSFITWVAAIDVRYQIWKFGVIFTDNSFLYLTWYMVMSLLGHYNNFFFASHLLDIAMGVKTLRTILSSVTHNGKQQVWGSYGSLCLTMTVGLLAVVVYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGDEYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDYFDTTPHGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDCFRKQYEDQLG",
"proteome": "UP000694405",
"gene": "LOC115945910",
"go_terms": [
{
"identifier": "GO:0005262",
"name": "calcium channel activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0070588",
"name": "calcium ion transmembrane transport",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0016020",
"name": "membrane",
"category": {
"code": "C",
"name": "cellular_component"
}
},
{
"identifier": "GO:0005515",
"name": "protein binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006816",
"name": "calcium ion transport",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0005219",
"name": "ryanodine-sensitive calcium-release channel activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006874",
"name": "intracellular calcium ion homeostasis",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0005216",
"name": "monoatomic ion channel activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006811",
"name": "monoatomic ion transport",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0055085",
"name": "transmembrane transport",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"protein_evidence": 4,
"source_database": "unreviewed",
"is_fragment": false,
"in_alphafold": false,
"in_bfvd": false,
"ida_accession": "da17a23f1a8abd482be628629cdaf4f44be746e2",
"counters": {
"domain_architectures": 7,
"entries": 46,
"isoforms": 0,
"proteomes": 1,
"sets": 5,
"structures": 0,
"taxa": 1,
"dbEntries": {
"pfam": 9,
"cathgene3d": 6,
"smart": 2,
"profile": 2,
"ssf": 4,
"cdd": 2,
"panther": 1,
"prints": 1,
"interpro": 19
},
"proteome": 1,
"taxonomy": 1,
"similar_proteins": 7
}
}
}
