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{
    "metadata": {
        "accession": "A0A8U0RUV8",
        "id": "A0A8U0RUV8_MUSPF",
        "source_organism": {
            "taxId": "9669",
            "scientificName": "Mustela putorius furo",
            "fullName": "Mustela putorius furo (European domestic ferret)"
        },
        "name": "Omega-hydroxyceramide transacylase",
        "description": [
            "Omega-hydroxyceramide transacylase involved in the synthesis of omega-O-acylceramides (esterified omega-hydroxyacyl-sphingosine; EOS), which are extremely hydrophobic lipids involved in skin barrier formation. Catalyzes the last step of the synthesis of omega-O-acylceramides by transferring linoleic acid from triglycerides to an omega-hydroxyceramide. Omega-O-acylceramides, are required for the biogenesis of lipid lamellae in the stratum corneum and the formation of the cornified lipid envelope which are essential for the epidermis barrier function. These lipids also play a role in keratinocyte differentiation. May also act on omega-hydroxylated ultra-long chain fatty acids (omega-OH ULCFA) and acylglucosylceramides (GlcEOS)"
        ],
        "length": 531,
        "sequence": "MEEQVFKGDPDTPHSISFSGSGFLSFYQAGAVDAFRDLAPRMLETTHRFAGTSAGAVIAALVICGIEMDEYLRVLNVGVAEVKKSFLGPLSPSCKMVQMMRQFLYRVLPEDSYKAATGKLHVSLTRFTDGESVVVSEYTSKEELIEARGGAQGAGALYCGCFVPVYCGLIPPTYRGVRYIDGGFTGMQPCSFWTDAITISTFSGQQDICPRDCPAIFHDFRMFNCSFQFSLENIARMTHALFPPDLLILHNYYYRGYEDTVSYLRRLNAAYLNSPSKRVMFPRVEVYCNIELALGSECPEHSQSSLQTEQEESIQPHTQWAPEGEGKSCHSPLVSSPVQTPESTHEWPVESPVSPLVSSFEQSPASPLASSPSHSPADLPPVSRPAVPLPLSSTPVLSHISPPQQRVQTTGSSPRSPPSQSPLSPRPFLGSSSVGTSQTLPLCSSVSPGQPPVEELGPEQPQAPLASSNLKDAMPLVNVKEATSKPHITGNPAEDSNWMSKMFKKNKQKTSSTRISFPRHPRSKKTGGKLQ",
        "proteome": "UP000000715",
        "gene": "PNPLA1",
        "go_terms": [
            {
                "identifier": "GO:0006629",
                "name": "lipid metabolic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0016787",
                "name": "hydrolase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0016042",
                "name": "lipid catabolic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "b5a6362642570e8fd6e064f1d2a86a1e30e1ba25",
        "counters": {
            "domain_architectures": 69623,
            "entries": 10,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cdd": 1,
                "cathgene3d": 1,
                "ssf": 1,
                "pfam": 1,
                "profile": 1,
                "panther": 1,
                "interpro": 4
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 69623
        }
    }
}