General Handler

HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept

{
    "metadata": {
        "accession": "A0A8N5ERE0",
        "id": "A0A8N5ERE0_GEOFO",
        "source_organism": {
            "taxId": "48883",
            "scientificName": "Geospiza fortis",
            "fullName": "Geospiza fortis (Medium ground-finch)"
        },
        "name": "Huntingtin-interacting protein 1",
        "description": [
            "Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner. Regulates presynaptic nerve terminal activity. Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. May play a functional role in the cell filament networks. May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors"
        ],
        "length": 1026,
        "sequence": "MPEQGLCKKSIVVMPLDSSMAHGACCSQVFLLAPFSEAPVTAGLLSSFPETVSINKAINAQEVAVKEKHARTCILGTHHEKGAQTFWSVVNRLPLSGNAVLCWKFCHVFHKLLRDGHSNVLKDSVRYKNELSDMSRMWGHLSEGYGQLCSIYLKLLRTKMEFHTKNPRFPGNLQMSDRQLDEAGENDVNNFFQLTVEMFDYLECELNLFQTVFSSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFLEQFRKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEASSPDSEPITDLVEMDAASQSLFDNKFDDIFGSSFSCDPFNFNSQNGMNKDDKDRLIEQLYGEITALKEELENFKAESARGAVQLRGRASELEAELAEQQHLKQQAQDESEFLRAELEELKKQREDTEKAQRSLTEIERRAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQITVARQAQGDVEQEKKELEDSFQRMTEQAQRKSQEQAEVLETLKRELAASRQELQVLQGTLESSTQAGVEQNTRIASLEQERDRLSQAAEQHRDKMAALQAELQQLRDTLSHEQESTELALQQRLAEEQLSLLQSTTREAEHMVQDALARMEDPAHISCTGSAGDAPVASAMGAEACAHCPAAAVGSLLPHLALFAHLVSNTLLQGSATSHVAPVEPADRLLELCKQCGSETVSYLSALQDPGKVASADCSLVTACLGQISAIGEELRPRGLDIKQEELGDLVDKEMAATAAAIEIASARIEEMLSKARAGDTGVQLEVNERILGSCTGLMQAIRVLVLASKDLQREIVESGRGAASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGKGTFEELMVCSREIAASTAQLVAASKVKADKDSANLCKLQQASRGVNQATASVVASTKAGKSQVEEKDSMNFSSMTLTQIKCQEMDSQVRVLELENQLQKERQKLGELRKKHYELAGVAEGWEEDAAD",
        "proteome": "UP000504602",
        "gene": "HIP1",
        "go_terms": [
            {
                "identifier": "GO:0005543",
                "name": "phospholipid binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0003779",
                "name": "actin binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0030276",
                "name": "clathrin binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006897",
                "name": "endocytosis",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "852be214f92d2c7bfe849e76fb82a5b7047cde6f",
        "counters": {
            "domain_architectures": 2207,
            "entries": 23,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "profile": 2,
                "cathgene3d": 4,
                "smart": 2,
                "pfam": 4,
                "ssf": 2,
                "panther": 1,
                "interpro": 8
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 2207
        }
    }
}