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{
    "metadata": {
        "accession": "A0A8M1F9Z3",
        "id": "A0A8M1F9Z3_URSMA",
        "source_organism": {
            "taxId": "29073",
            "scientificName": "Ursus maritimus",
            "fullName": "Ursus maritimus (Polar bear)"
        },
        "name": "Receptor-type tyrosine-protein phosphatase",
        "description": [
            "Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+)"
        ],
        "length": 700,
        "sequence": "MEPFCPLLLAGVSLPLAKALKGNETTSAVSNQTSTTSGPPRGAPQPLLAWLLLPLLLFVLLLLLAAYFFRFRKQRKAVVSANDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVAHLEEEIRVRSADDCKRFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQVDGTPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMIWEQKSAIIVMLTNLKERTEEKCSQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQSQLPEGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKALNPAHAGPIVVHCSAGVGRTGTFIVIDAMMDMMHAEQKVDVFDFVSRIRNQRPQMVQTDTQYTFIYQALLEYYLYGDTELDVSSLEKHLQTLHGSTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMVWEWKCHTVVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKSDTLSEAISIRDFLVTFNQPLGHQEEQTRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYANFK",
        "proteome": "UP000261680",
        "gene": "PTPRE",
        "go_terms": [
            {
                "identifier": "GO:0004725",
                "name": "protein tyrosine phosphatase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006470",
                "name": "protein dephosphorylation",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0016311",
                "name": "dephosphorylation",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "795885d7da2068563b81e8d236574be7145191cd",
        "counters": {
            "domain_architectures": 10602,
            "entries": 20,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 1,
                "ssf": 1,
                "smart": 2,
                "profile": 2,
                "pfam": 1,
                "cdd": 2,
                "pirsf": 1,
                "panther": 1,
                "prints": 1,
                "prosite": 1,
                "interpro": 7
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 10602
        }
    }
}