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{
    "metadata": {
        "accession": "A0A8J1MWU4",
        "id": "A0A8J1MWU4_XENLA",
        "source_organism": {
            "taxId": "8355",
            "scientificName": "Xenopus laevis",
            "fullName": "Xenopus laevis (African clawed frog)"
        },
        "name": "MAP kinase-activating death domain protein",
        "description": [
            "Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family. Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion. Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction. Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses. Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals. Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2. May link TNFRSF1A with MAP kinase activation. May be involved in the regulation of TNFA-induced apoptosis"
        ],
        "length": 1636,
        "sequence": "MGQRKKPCPRLLDYLVIIGARQPSSDSISQTPELLRRYPLEDHPEFPLPPDVVFFCQPEGCLSVRQKRMSLRDDMSFVFMLTDKDSGVIRYGICVNFYRSFQKRLPKDKSRKPPKPASENGSEGSDGGHPMQPHSADSTPDLNHSPRGKRLSKGTQRSRNSTLTSLCIISHYPFFSTFRECLYTLKRLVYCCSERLVSKKAGINKVVQRDTMWRIFTGSLQLEEKPNVLLHDLREIEAWIYRLLRSPTPVPGQKRVDIEVLPLDHQPPLTFALPEPSRFSLVDFPLHLPLELLGVEACLQVLSCIMLEHKVVLQSRDYNALSMSVMAFVSMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKSDFRMPDDVWLVDLDTNKVVAPTNAELLPVLPEPEASELKKHLKQALASMSLNTQPILNLDRFHEGADAALLKAPNDAQGTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSPNMLQNFQMHTRTLRLFPRPVVAFQSSSFLAARPKPTLFTEKLSKTQAVEFFGEWSLNPTNFAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDANSQLAEAFSVPAERDSDSDPTDDSGSDSVEYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAALGDASEVEFDDFQEYSGEIEENNGDSENSPDNNQPHSGSSTTASSSPSTVIHGAITESADSAEPEEKVMGVLQNHLPVLPPTFTRIAMERRESDVSLGGGETRRREYDNPYFEPQYGFPPEEENEEREESYTPMFNQNMNGTRSPKPLLRPNSLKLASDSDAETDSRGSSPTSNNSSNNEGFGGIMSFASNLYKTHSSSFSLSSLTLPSKSRDKATPFPSLKVFGLNTIMEIIADSGPAPAEGSNRRALVDQKSSGIKHSPTVKRESPSPQGKSNNSSENQQFLKEVALGVLEGQGVGWLNMKKVRRLLESEQLRIFVLSKLNRSIQTEEDARNDVIQEVEITRKVYRGMLDLLKCTVSSLEQTYANAGLGGMASVFGLLEIAHTHYYNKEPEKRKHSPSADGAVTPVSRDPVSAPRVESRPAPQLPAKQLLPRPSGPAGRGPREFDTRSLKEENFVASIELWNTHREVKKQKAMDKQSTKKAPPLVDSGETEEKKSQISADSGLSVTFGSQRSDLDTGSVGPSILIRSSSQDSEISTVSNSSGETLGADSDLSSNAGDALGGPGGSHLSGSRGAVSDSEIQMNSFTGAIFGKPQMLRPGEKERNVSPGRPQQDLSQRIYLYEGLLGREKGSVWDQLEDAAMETFSLSKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYFSLVVHDRKRLEDDEDRLLGTLLHNMIAYMIMMKVNKTDLRRKIRRILGKCHIGLVHSQQINELLDRVTDMIGRDLSIRPSGSRHIKKQTFVVHAGTDTSGDLFFMEVCDDCIVLRSNIGAVYERWWYEKLINMTYCPKTKVLCLWRRNGQETQLNKFFTKKCRELYYCVKESMERAAARQQSIKPGPELGGEFPVQDMKTGEGGLLQVTLEGINLKFMHSQVFIQLNHIKKCNTVRGVFVLEEFVPETKEVVSHKYKTPMAHEICYSVLCLFSYVAAIRGKEAELKSRTPRPVSS",
        "proteome": "UP000186698",
        "gene": "madd.L",
        "go_terms": null,
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": false,
        "in_bfvd": false,
        "ida_accession": "1661a65e43513d6ed0ca85f9f744b57acf95d6a6",
        "counters": {
            "domain_architectures": 4907,
            "entries": 21,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 4,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 2,
                "smart": 3,
                "profile": 1,
                "pfam": 5,
                "panther": 1,
                "interpro": 9
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 4907
        }
    }
}