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{
    "metadata": {
        "accession": "A0A8D2KW33",
        "id": "A0A8D2KW33_VARKO",
        "source_organism": {
            "taxId": "61221",
            "scientificName": "Varanus komodoensis",
            "fullName": "Varanus komodoensis (Komodo dragon)"
        },
        "name": "Complement C4 gamma chain",
        "description": [
            "Precursor of non-enzymatic components of the classical, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system",
            "Putative humoral mediator released following cleavage by complement proteases (C1S, MASP2 or GZMK, depending on the complement pathway). While it is strongly similar to anaphylatoxins, its role is unclear. Was reported to act as a mediator of local inflammatory process; however these effects were probably due to contamination with C3a and/C5a anaphylatoxins in biological assays"
        ],
        "length": 1717,
        "sequence": "MSSGKWVPLWLIWMGTLVALSQQAPRLLMVAPSVVTVGTEVGVVLQVEGAPSGLSGTVFFRNQNSMVKCSQEVPFSLQSSGFIQKVTLKVTHELFVQCALSKQRRNHYIQLVAHSTQLPSSNGIQTLDLRWSSRRGYLFVQTDKPIYTPRQKVNFRVFVLDDKLRPSAESVTITIQNPRGVQVRKAELMPVHFVIKDHLSIPDISEPGIWRITAAFVNALGSNTTTEFEVKKYVLPHFDVKIVPEQKYILVSEQQDSDLKIDIQAKFFYGKGVTSTAYVRFGIIDDNGKKIFISGLEQQVLVTEGLGSLTLKCSLLSEKLGRSLQDLVGTTLYIAATVIETASGELEEQELSSVKFVSSPYTVDLSKTKQHFVPGAPFDVLVAVSLPDGTPARHLPVHFSAQITGGSSVDDAQMDTNDKGLVMQRINISPRATSITITVTAGTESPAEVTLTAKAMTSLNRNYLIIESPKYQGWNPGDTITLGLKNVGSDAFSHFYYMVLSKGDIVSADKVARGSYVSVPIPITHDLMPTFRFVAFYRIGDEVVANSIWVDVVDRCEGKLEISVVGNRNEWKPQDQLTLSIKTDESSVVSLGATDSAVYALGRKNRLTQGKVFQAMGSYDLGCTAGSGKDTLSVFADAGLSIRSGELRSPLRIAHGCSEVASRKKRSLQLHLELQKKLSKYQDPESQRCCQGGMVLLRQHLRCENRAKRIQGPDSQKCRDAFLDCCKHAESLRRTSRNSQSVARTQDEEDEDWFNDEFIQVRSVFPESWLWKSYTVNNILTERIILPDSITTWEIQAVSMSSQRGICISEPLQVRVFQDFHISLRLPYSVKRFEQIELRPVLYNYQSAPIQASVYLEPAEGICSPATVGPERKRKVEIPGNSAVPVPFVLVPMGASDIPITVAAIGDWGIGDKVSKKLRVEREGAVHVEEFTIPLDNIDGVSRSLEISGEVPTNAIPDGDFKMSVRLTGSVPTDTLESSLTPDGLSSLLRVPRGCGEQTMILMAPGIYAMRYLDKTEQWLRLKAESKEKALENLRTGYERILTFRKEDGSYGAWLSRPSSTWLTAFVVKVLSLSREYHAVEDSKIRETVQWLLRKQESDGSFKDPAPVYHREMQGGVGGLHGGISLTAFVTIAIKEAMVAYSGGDAEMQQQLSQVRNSLDRATAFLAGKMNDLSLGSYPIAITSYALSLASSDQSAIIAAGTRLKDLASQDQNKTVLFWAVEEQDRLRGETSNRVPSASAISVEATSYALLYLVKQDDITTAGQVSRWLTEQRNYGGGFKSTQDTVVALEALSNYWISTFKEEGNELEVTLNLPGKSLPVFLSFGRSNDPVQKELQFPLGSTIGVSVQGKGKGILTVLKQYYVLTMQNTSCQTLGLEVTVSGSVQRDIGADDYYYEYEYDGGGGPAAQPADQPLSSIGLFDARQRRRREVKDPGEPRRDVSYNVCFWRQPGAHVTGMVIIDITLLSGFQPDENDLNQLRDVPDQYISHWEIQGQRLLLYIESVPDSGRECIVFRAKQTVPVGKLQPSSATIYDFYEPDKRCNIFYGAPNNPQYVSALCSDDVCQCAEGACPRLKHTLEDALTEDARVDFACYIPIIHYAFRVRVERESKESAFRIYEVEILEVLKFTADVDISTKSTRRFVVRAACRTRLSTGSEYLLMGHDGETQDPQSRPQYLLDRNSWVEEVPKPLQCQATRHRNTCAQLQKFTTSFAMNGCRS",
        "proteome": "UP000694545",
        "gene": "LOC123017777",
        "go_terms": [
            {
                "identifier": "GO:0004866",
                "name": "endopeptidase inhibitor activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005576",
                "name": "extracellular region",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            },
            {
                "identifier": "GO:0005615",
                "name": "extracellular space",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            },
            {
                "identifier": "GO:0005515",
                "name": "protein binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": false,
        "in_bfvd": false,
        "ida_accession": "64803ac02e30f7f155dc07997ebe88ead63706a2",
        "counters": {
            "domain_architectures": 308,
            "entries": 57,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 5,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 10,
                "pfam": 11,
                "smart": 6,
                "cdd": 2,
                "ssf": 4,
                "profile": 2,
                "panther": 1,
                "prosite": 1,
                "interpro": 20
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 308
        }
    }
}