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{
    "metadata": {
        "accession": "A0A8C9RA56",
        "id": "A0A8C9RA56_SCLFO",
        "source_organism": {
            "taxId": "113540",
            "scientificName": "Scleropages formosus",
            "fullName": "Scleropages formosus (Asian bonytongue)"
        },
        "name": "MAP/microtubule affinity-regulating kinase 3",
        "description": [
            "Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1"
        ],
        "length": 743,
        "sequence": "MSARTPLLTVIENSSSQPYSDAKASGRSSMSRGRNSFATTADDQPHIGNYRLLKTIGKGNFAKVKLARHVLTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDGDMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPTKRGSLEQIMKDRWMNVGHEEDELKPYVEPQPDYKDPRRTEIMLQMGYSQDEIQDSLVNQKYNDVMATYLLLDYKTSEGDEVLTIKPRPGSDLTNSNVQSPPHKVQRSVSSNPKPRRSTDQGCSSYSKRSQGDSKHTVEESARKGSGSSTKVPPSPLTLGDHTKGTPTPSTNSILSTGTSRSRNSPLTERSTLGQGIQNGKDSAASQRAPGASPSAHNISNATMADRTNFPRGVASRSTFHAGQQRATRDQQASANGPPASPSLSHGNSQPRRPGAAGIFSKFTSKFVRRNLSFRFPRRSPYEGEGRDEGSRPMLSSSGDKSEKGPGSMLGSTGDENKDSLSSSSPVPGGTPPPKDPKPRSLRFTWSMKTTSSMEPSEMMKEIRKVLDSNSCEYELRERYMLLCMSGDPSRDNFVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL",
        "proteome": "UP000694397",
        "gene": "MARK2",
        "go_terms": [
            {
                "identifier": "GO:0004674",
                "name": "protein serine/threonine kinase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0004672",
                "name": "protein kinase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005524",
                "name": "ATP binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006468",
                "name": "protein phosphorylation",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "41c929664501752aa367c8370f78a987cdcbbfe0",
        "counters": {
            "domain_architectures": 7295,
            "entries": 27,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 5,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 4,
                "ssf": 2,
                "cdd": 2,
                "profile": 3,
                "smart": 2,
                "pfam": 3,
                "panther": 1,
                "prosite": 2,
                "interpro": 8
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 7295
        }
    }
}