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{
    "metadata": {
        "accession": "A0A8C8Y6Q4",
        "id": "A0A8C8Y6Q4_PANLE",
        "source_organism": {
            "taxId": "9689",
            "scientificName": "Panthera leo",
            "fullName": "Panthera leo (Lion)"
        },
        "name": "Dual specificity protein kinase TTK",
        "description": [
            "Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments. Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint. Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore. Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments. Phosphorylates KNL1, KNTC1 and autophosphorylates. Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment"
        ],
        "length": 839,
        "sequence": "MEAEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKVSADTTDNSGTVNQIMMMANNPEDWLNLLLKLEKNSVPLNDALLNKLIGRYSQAIEALPPDKYGQNESFAQIQVRFAELKAIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNFKKSKQLLHKAVECGAVPLEMLEIAIRNLNLQKKQLLSEDEKKSLSASTILTAQESFPNSLGHLQNRNISCDSRGQTTKAKFLYGENLPPQDAEIGHRNPLKQTKKAKRSCPFGRVPVNLLSSPDYGKTDDSVVPSFTKRQTSGSERQDMIVPGSKSSGNDSSELRNLKSIQNIHSKEPLMSDEKSSELITDSVTLKNKTESSLLSKLEEIKEHQEPKVPESNQKQWQSKRKSECINQNPAVSSNQWQIPDTAQKVDTEQKQTTFEQPAFSVSKQSPPISAPKWIDPKSVCKTPSSSALDDYMSCFRTPVVKNDFPPACQLSTPYSQLACFQQQQQQIPVTPLQTLQISASSSTNECISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIHAIKYVNLEEADNQTIDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSVNPWERKSYWKNMLEAVYTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSIVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQHIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLIRDPKQRISIPELLVHPYVQIQTHPGNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKVRMSVLYLHYF",
        "proteome": "UP000694399",
        "gene": "TTK",
        "go_terms": [
            {
                "identifier": "GO:0005515",
                "name": "protein binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0004672",
                "name": "protein kinase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005524",
                "name": "ATP binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006468",
                "name": "protein phosphorylation",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "726173b0dde7bbc50c5d845a39c992d18faf18f3",
        "counters": {
            "domain_architectures": 887312,
            "entries": 16,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 3,
                "ssf": 2,
                "cdd": 1,
                "pfam": 1,
                "smart": 1,
                "profile": 1,
                "panther": 1,
                "prosite": 1,
                "interpro": 5
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 887312
        }
    }
}