General Handler

HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept

{
    "metadata": {
        "accession": "A0A8C8JDF3",
        "id": "A0A8C8JDF3_ONCTS",
        "source_organism": {
            "taxId": "74940",
            "scientificName": "Oncorhynchus tshawytscha",
            "fullName": "Oncorhynchus tshawytscha (Chinook salmon)"
        },
        "name": "Helicase POLQ-like",
        "description": [
            "Single-stranded 3'-5' DNA helicase that plays a key role in homology-driven double-strand break (DSB) repair. Involved in different DSB repair mechanisms that are guided by annealing of extensive stretches of complementary bases at break ends, such as microhomology-mediated end-joining (MMEJ), single-strand annealing (SSA) or synthesis-dependent strand annealing (SDSA). Possesses both DNA unwinding and annealing activities. Forms a complex with RAD51, stimulating HELQ DNA helicase activity and ability to unwing DNA. Efficiently unwinds substrates containing 3' overhangs or a D-loop. In contrast, interaction with the replication protein A (RPA/RP-A) complex inhibits DNA unwinding by HELQ but strongly stimulates DNA strand annealing. Triggers displacement of RPA from single-stranded DNA to facilitate annealing of complementary sequences"
        ],
        "length": 1031,
        "sequence": "MSAEIKVKRQSSRKRSRDRRISHLTPARKRTSASGRQCPDNTGQIELSRALDKSMDAKFSEYCSDPEDLFGDYDSIVSDSSFLAKLDRVGQNMRPHDIDHTTSSRCPVILLAGNPDFTSLKSSTDNCPKQSCDDSMTESFLEGFTDDAFLDMPSSQLAFLQDPQTADRNCCTDEDKTSMPMRHPEKSVSTEERNERHIAPKARKSVSDHLKRAMMANAATPSSVSRTAVQKEAVVTEEISVAMQAMESVSMATTDLGPFFGLPTKVKELICNLKGIKDLYEWQKTCLNLDSVQQRRNLIYSLPTSGGKTLVAEILILKEILCRKKDALFILPYVSLVQEKVRGLASFGLELDFMVEEYAGSKGRFPPVKGRGKRSLYIATIEKAHGLVNSLIETNRLDNVGLVVVDELHMLGDGSRGAIIEMTLAKVLYISKSTQIIGMSATLGNLQDIQKFLKAESYTNDFRPVELKEYVKLKDSIYEVDPKEEECFRFSRVLNFKYSSAMQKIDQDHIVALVTEVIPSQSCLVFCPTKKNCENVAGMICKYLKEDFIQHKQAEKAVLLGELRSSGNGSLCPVLKKTVPYGLAYHHSGLTSEERKLVEEAYSAGVLCLLTCTSTLAAGINLPARRVILRSPYVAADFLKRSQYKQMVGRAGRAGIDTHGESILILQDKDKVLVKKLVSAPMEICKSNLMHSDGKGVLSLILSVIGLNITNSLEQIRDFMSGTLLSVQEKQVCLERSLWEVTQECVELLKEKGLVTVSTEPQDGSLQVTKLGRATYKGSVDLTYCDLLYRDLSKGLESLMLNSFLHLIYLVTPYDMVSQCKPDWMVYFRQFTMLSAAEQKMCAAVGVSESFVARKAAGQNVKKNVDQVVVSRLYLALVLQSLLKETDLWSVADRFQLSRGFIQTLLSSSSVFCSCVLHFTEELEEFWPFKALLTELTRRLTYCVQAELIPLMEVAGVMERRAKQLYNAGYKTLAHLANADPNVLAKTVENLFKKQANQIVASAKMLLNEKADALQEEMDDLLMMPLDLLSL",
        "proteome": "UP000694402",
        "gene": "HELQ",
        "go_terms": [
            {
                "identifier": "GO:0003676",
                "name": "nucleic acid binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005524",
                "name": "ATP binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "3beecf8cb5835029bef32c18997ba79018cf274c",
        "counters": {
            "domain_architectures": 1410,
            "entries": 17,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 4,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cdd": 2,
                "smart": 2,
                "profile": 2,
                "pfam": 4,
                "panther": 1,
                "interpro": 6
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 1410
        }
    }
}