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{
    "metadata": {
        "accession": "A0A8C4HVJ4",
        "id": "A0A8C4HVJ4_DICLA",
        "source_organism": {
            "taxId": "13489",
            "scientificName": "Dicentrarchus labrax",
            "fullName": "Dicentrarchus labrax (European seabass)"
        },
        "name": "Thromboxane-A synthase",
        "description": [
            "Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE"
        ],
        "length": 535,
        "sequence": "MESVVDFLNVFHIRASGLSVTLSLFLISLGLLYWYSIYPYSVLSRCGIKHPKPIPFLGNIFMFRQGFFSPINELIKTHGRVCGYYLGRRPVVVVADPDMLRQVMVRDFSSFPNRMTVRFATKPMTECLLMLRNERWKRVRSILTPSFSASKMKEMVPLINTATDALMNNLNVYAESGEAFDIHKCFGCFTMDVIASVAFATQVDSQNNPDDPFVRHAQMFFSFSFFRPIMLFFIAFPFIMAPLAGLIPNKRRDQMNQFFINSIQKIIQQREEQPPEQRRRDFLQLMLDARTSKESVSLEHFDSANPSGVTDHRNQQTRPPASDQEHPQEPPTRRPQKKMITEDEIVGQAFVFLLAGYETSSNTLAFTCYLLAIHPECQVKVQEEVDDFFTRHESPDYTNVHELKYLDMVISEALRLYPPGFRFARDIDNDCVVNGQFLPKGATLEIPAGFLHYDPEHWPEPEKFIPERFTPEAKASRHPFVYLPFGAGPRNCVGMRLAQLEIKMALVCLFRRFSIVACTETKLLCSLRSFSQQPF",
        "proteome": "UP000694389",
        "gene": null,
        "go_terms": [
            {
                "identifier": "GO:0004497",
                "name": "monooxygenase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005506",
                "name": "iron ion binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0016705",
                "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0020037",
                "name": "heme binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "e3099b6a964c63c7481beb4be664022a4b67f85a",
        "counters": {
            "domain_architectures": 38192,
            "entries": 12,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 0,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 1,
                "ssf": 1,
                "pfam": 1,
                "panther": 1,
                "prosite": 1,
                "prints": 2,
                "interpro": 5
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 38192
        }
    }
}