General Handler

HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept

{
    "metadata": {
        "accession": "A0A8B9R854",
        "id": "A0A8B9R854_ASTMX",
        "source_organism": {
            "taxId": "7994",
            "scientificName": "Astyanax mexicanus",
            "fullName": "Astyanax mexicanus (Blind cave fish)"
        },
        "name": "Renin receptor",
        "description": [
            "Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission"
        ],
        "length": 339,
        "sequence": "MRGVLGDQLTVLRSPQYVTFREGQWPLAGEKVPDLVALTMGFSVQEDLDWPGLGAGSLFQRPRANALIAVRGVSSLDLPSNTSSYPLENPVPFTLDSVANTIHTLFAESTPVVLQLAPSEERLYMMGMANTVFEDLPVTLQQIRARLSQEGSVLHSLPLHSLNRNSEADLLFLSEVQVLHDISALLLRHKHLAKDQAPDLFSLELAGLEEISRRYGSDSPQFQDASKILASALQKFADDVYSVYSNNAVVEVVTVKTFEAPLTRKSRSILESKQISNPGSPYNLAYKYNYEYAVIFNIVLWLMIALALAVIAIAYNLWNMDPGYDSIIYRMTNQKIRMD",
        "proteome": null,
        "gene": "atp6ap2",
        "go_terms": [
            {
                "identifier": "GO:0038023",
                "name": "signaling receptor activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0016020",
                "name": "membrane",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            }
        ],
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "2005cc047a5411db7e515852e1c429327b3a6753",
        "counters": {
            "domain_architectures": 1775,
            "entries": 6,
            "isoforms": 0,
            "proteomes": 0,
            "sets": 1,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "pfam": 2,
                "panther": 1,
                "interpro": 3
            },
            "proteome": 0,
            "taxonomy": 1,
            "similar_proteins": 1775
        }
    }
}