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{
    "metadata": {
        "accession": "A0A8B7ADG3",
        "id": "A0A8B7ADG3_ORYAF",
        "source_organism": {
            "taxId": "1230840",
            "scientificName": "Orycteropus afer afer",
            "fullName": "Orycteropus afer afer"
        },
        "name": "E3 ubiquitin-protein ligase",
        "description": [
            "E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates"
        ],
        "length": 266,
        "sequence": "MLFFTQCFGAVLDLIHLRFQHYKAKRVFSAAGQLVCVVNPTHNLKYVSNRRAIAQSTPEQANFHPHHLTHHHRHHCHHHHLRHHAHPHHHHQEVGLHNAQVTPCMCPLFSCQWEGHLEVVVPHLRQTHRVDILQGAEIVFLATDMHLPAPADWIIMHSCLGHHFLLVLRKQEKHEGHPQFFATMMLIGTPTQADCFTYRLELNRNHRRLKWEATPRSVLECVDSVITDGDCLVLNTSLAQLFSDNGSLAIGIAVTAVNVHHTEIEI",
        "proteome": "UP000694850",
        "gene": "SIAH3",
        "go_terms": [
            {
                "identifier": "GO:0005515",
                "name": "protein binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006511",
                "name": "ubiquitin-dependent protein catabolic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0007275",
                "name": "multicellular organism development",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0005737",
                "name": "cytoplasm",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "8c04353d814a20e39de15bbacbf54ff47e6948ad",
        "counters": {
            "domain_architectures": 633,
            "entries": 9,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "ssf": 1,
                "cathgene3d": 2,
                "cdd": 1,
                "pfam": 1,
                "panther": 1,
                "interpro": 3
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 633
        }
    }
}