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{
    "metadata": {
        "accession": "A0A850ZF86",
        "id": "A0A850ZF86_9PASS",
        "source_organism": {
            "taxId": "237442",
            "scientificName": "Tichodroma muraria",
            "fullName": "Tichodroma muraria"
        },
        "name": "Acyl-coenzyme A thioesterase 8",
        "description": [
            "Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs. Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains. Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT). Is also able to hydrolyze CoA esters of dicarboxylic acids. It is involved in the metabolic regulation of peroxisome proliferation"
        ],
        "length": 301,
        "sequence": "GDLRSVLITSVLNLERLEVDLFRCAGQHHWVPATQHLFGGQIVGQALVAAAHAVSRDEQVHSLHCYFVRTGDPKVPVLYEVERTRTGKSFSVRSVKAIQHGKPIFTCQASFQLSQGSPVQHQFTMPTVPPPEELLTQEELIQKFLQNPNVAEGYRKRLTKIQAQDVPIDIKPVNPPDIFSLEPQEPKQLFWVRARGYIGETDMKVHCCVAAYISDYAFLGTALLPHRQYRVKFMVSLDHSMWFHAPFRADHWMLYECESPWAGGCRGLVQGRLWRRDGVLAVTCAQEGVIRVEQTPNQSKL",
        "proteome": "UP000629438",
        "gene": "Acot8",
        "go_terms": [
            {
                "identifier": "GO:0047617",
                "name": "fatty acyl-CoA hydrolase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006637",
                "name": "acyl-CoA metabolic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": true,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "fd1a9168905e51b62daba36d9e70782041295dfb",
        "counters": {
            "domain_architectures": 13240,
            "entries": 13,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 1,
                "ssf": 1,
                "cdd": 2,
                "pfam": 2,
                "panther": 1,
                "ncbifam": 1,
                "interpro": 5
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 13240
        }
    }
}