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{
    "metadata": {
        "accession": "A0A834AP36",
        "id": "A0A834AP36_9CHIR",
        "source_organism": {
            "taxId": "89673",
            "scientificName": "Phyllostomus discolor",
            "fullName": "Phyllostomus discolor (pale spear-nosed bat)"
        },
        "name": "RUN and FYVE domain-containing protein 4",
        "description": [
            "ARL8 effector that promotes the coupling of endolysosomes to dynein-dynactin for retrograde transport along microtubules. Acts by binding both GTP-bound ARL8 and dynein-dynactin. In nonneuronal cells, promotes concentration of endolysosomes in the juxtanuclear area. In hippocampal neurons, drives retrograde transport of endolysosomes from the axon to the soma. Positive regulator of macroautophagy in dendritic cells. Increases autophagic flux, probably by stimulating both autophagosome formation and facilitating tethering with lysosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE-type zinc finger. Positive regulator of osteosclast bone-resorbing activity, possibly by promoting late endosome-lysosome fusion by acting as an adapter protein between RAB7A on late endosomes and LAMP2 on primary lysosomes"
        ],
        "length": 570,
        "sequence": "MAEEGTALKVTRDLKAAVSAILQGYGGGHRVTDASAELHRLCGCLEQLLQFDQKQQKSFLRPRKDYWDFVCAALWQQRGNTEPARFVHSQDRLKTPLGKGRAFIRFCLAHGQLAEWLQLCLLSPPLTREWYGPRSPLVHPDLQEDILDSLYALNGVAFDLDLQRPDLDGAWPMFSESRCSNSSRTPGRRPRKNRDSPKETSAVRGSPKGVLPEEPHTSQASSLQDAPADQLAGLLTSQQNGHLPPFLEVKKDDPRSLGVPHSMWEPEGEEPQQDQDMGAPRASLCLGNSTLSIQGQGEEARRALKEVVETECEGRGVLLSAGGQRTTEGTREREAEWGHVQRLLVSSSRGTNEDTMSRSRGEGKVPGILGEPSVLQSLGTKGGSATEKPQEQTGVTSVTRTEDEGADVALQDAVESLRHRLQKTKEQAQHQEQLRKEQDMQLKALQEQLTRCQEERARLQAELEQKQREAERRSAVYEEELRGQRDLVQAMKRRVLELIQEKDNLWQKAQHLSSVAPGCCIGCSKVFGRLSRRYPCRLCGGLVCRACSVGYKKQEHRCPSCAQKGEAQGV",
        "proteome": null,
        "gene": "HJG60_016743",
        "go_terms": [
            {
                "identifier": "GO:0016239",
                "name": "positive regulation of macroautophagy",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "42da999b307c746c74547cec70f8d00cc949334c",
        "counters": {
            "domain_architectures": 278,
            "entries": 14,
            "isoforms": 0,
            "proteomes": 0,
            "sets": 1,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 1,
                "ssf": 2,
                "profile": 1,
                "smart": 1,
                "pfam": 2,
                "cdd": 1,
                "panther": 1,
                "interpro": 5
            },
            "proteome": 0,
            "taxonomy": 1,
            "similar_proteins": 278
        }
    }
}