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{
    "metadata": {
        "accession": "A0A803TZS0",
        "id": "A0A803TZS0_ANOCA",
        "source_organism": {
            "taxId": "28377",
            "scientificName": "Anolis carolinensis",
            "fullName": "Anolis carolinensis (Green anole)"
        },
        "name": "Phosphoinositide phospholipase C",
        "description": [
            "The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function"
        ],
        "length": 603,
        "sequence": "METRWFLNVIHKKFKKGKLSFENTLELLGNFDIPFDYIHVKYIFKARNSLKSGTIGLDDFRGIYQAIAHRSEIHELFKTHSPNHKVLPLSNLVAFLKNEQFQLEADETTASQLIAKFEPIEEARRNSEMTFEGFLRYMTSEDCMIFKTEHQSVYQDMTRPLCEYFISSSHNTYLISDQLIGPSHLWGYASALMKGCRCLEIDCWDGPCNDPVVYHGHTLTSKISFKTVIQVINKYAFLVSNYPLLLSLENHCSPRQQEVIADYLTSILGDKLVTSTIDDKMPNELPSPEALKFKILIKNKKLGTLEETLARRGIDKCHSSCQSIGQWSPGVLMKKIKMALELSDLVIYAKTRQFVSFEDSRENQLFYENTSIGEGRARKLEKLQADEFIQHTARFLTRIYPKGTRTTSSNYNPQEFWNVGCQLVALNFQTPGLQMDLQTGKFLDNGGSGYILKPEYLRRIDPEFSPYTLATNRLPVLLTIKLISGHQLPPSSLSSTNKANPLVVIEIYGVPEDQAKQHSCVVKGNALCPRWNETFTFNIQVPELALVRFAVEDQLSLTANDLLGQYTLPFLSMNKGYRQVPLLSKLGVSLRPASLFVHVWYFD",
        "proteome": "UP000001646",
        "gene": "LOC100555994",
        "go_terms": [
            {
                "identifier": "GO:0008081",
                "name": "phosphoric diester hydrolase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006629",
                "name": "lipid metabolic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0004435",
                "name": "phosphatidylinositol-4,5-bisphosphate phospholipase C activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0007165",
                "name": "signal transduction",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0035556",
                "name": "intracellular signal transduction",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "e36128bbf200eff3804e5cac40701d1a723cf418",
        "counters": {
            "domain_architectures": 3275,
            "entries": 27,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 4,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "ssf": 3,
                "pfam": 4,
                "cathgene3d": 3,
                "smart": 3,
                "profile": 3,
                "cdd": 1,
                "panther": 1,
                "prints": 1,
                "interpro": 8
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 3275
        }
    }
}