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{
"metadata": {
"accession": "A0A7S8F1X7",
"id": "A0A7S8F1X7_PVMA",
"source_organism": {
"taxId": "12215",
"scientificName": "Potato virus A",
"fullName": "Potato virus A (PVA)"
},
"name": "Genome polyprotein",
"description": [
"Has helicase activity. It may be involved in replication",
"Involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification",
"Mediates the cap-independent, EIF4E-dependent translation of viral genomic RNAs. Binds to the cap-binding site of host EIF4E and thus interferes with the host EIF4E-dependent mRNA export and translation. VPg-RNA directly binds EIF4E and is a template for transcription. Also forms trimeric complexes with EIF4E-EIF4G, which are templates for translation"
],
"length": 3059,
"sequence": "MATQAIMVGEFKILEVNCKPHTPVAAIHVPTQTPKTNDIQWANLELTLAKSLQRQAHGVVKVDKHGTARIKRASKHHMSCLEQQMADEVAEKEAFMAAPTQLVTSIIFAGTTPPSMMETETIVKKIHTVGKHAKVMRKRSYITPPTDKSLRNHGVIPYSVQQLCRTLGNLSKRTGISLEVVGKTSKATKLRFTKTSFGYMARVQLKHHDGRMHRRDLVVDTSTTTIMQTLFLKTARTNANLDVLTHGSSGLVFWNYLVTGQRMRTRDNFIIVRGRCNGILVDARAKLSESTMLSTHHYSTGDVFWRGFNRTFLENKPINLDHVCSSDFSVEECGSIAALICQSLLPCGKITCRACAAKNLNMDEDTFKEFQTQRAREISAVIISKYPDFACVSQFIDRYFSHQRVLNPNVNAYREILKIVGGFTQSPYTHIQELNEILVLGGRATPEQLGSASAHLLEITRFVRNRTDNIKKGSLALFRNKISAKAHVNTALMCDNQLDRNGNLIWGERGYHAKRFFSNYFDIITPGGGYKQYIERRVPNGIRKLAIGNLIVTTNLEALREQLEGESIEKKAVTKACVSMSDNNYKYPCCCVTLDDGTPLYSTFIMPTKNHLVIGNSGDPKFLDLPTDISTQMYIAKSGYCYINIFLAMLVNVDESDAKDFTKKVRDIIVPDLGEWPTLIDVATSCSLLSAFYPATSAAELPRILVDHDLKTMHVIDSYGSLNTGYHVLKANTVRQLIQFASNSLDSEMKHYRVGGTPNSQINGYATIKMLAKAVYRPKLMKEIIHEQPYMLVMSLMSPGILIALANSGALEMGIHHWIREGDSLVKMAHMLRTVAQNVSVARATWVQQEIISDSAQQMLETILNGTIPNVSYFQAIQYLTMLAASKEVDAEVRVTGYYTFKLQTSELLEKTYLSLLEDSWQELSYFGRFQAIRHSRRYCTAGTIVVKPERHVDLGGIYATSYQFALAKQMEYSKKAVCQAVNGLQARFNNIISQIYCKILNWPKRLFPDLVKFINTMLAITVALQLYIAFATILRHHQQCKQDSLELEYCKKERQLITLYDFFIAKQPYATEEEFMAHVDEQNPDLSNFAREYCAEVVLFQAKASEQVNFERIIAFISLVLMMFDCERSDCVYRSLTKLKSLMSTVENTVQFQSLDDIGPTLEEKNMTIDFDLDTDTIVGKSIVGHTFKEWWDVQLNTNRIVPHYRTEGHFMEFTRANAPTIAHQISHDLHTDIMLRGAVGSGKSTGLPYHLSKKGTVLLLEPTRPLAENVTKQLKSDPFHVSPTLRMRGMAVFGSTPIHVMTTGFALHYLANNLKMLSTYDFIIIDEFHVHDSNAIALRNLLHEHNYQGKLIKVSATPPGREVEFSTQYPVEIRVEDQVSFQDFVKAQGNGSNLDLTSKCDNLLVYVASYNEVDQLSKLLLERHFLVTKVDGRSMKLGQVEIITKGSANKKHFIVATNIIENGVTLDIDAVIDFGMKVVPFLDSDNRMISYNKVSISYGERIQRLGRVGRNKAGVALRIGHTEKGISDVPVVIATQAAFLCFVYGLPISTQSVTTQVLSNVTLKQARTMVQFELPIFYMAHLVRYDGTMHPAIHNELKKYKLRDSEIQLSKLAIPSKCVPIWMTGKAYRLLTHNSQIPDAVRVPFLTKEIPDKLHENVWAIVEKFKCDAGIGRMTSAQASKVAYTLETDIHSIQRTILIIDQLLEREMQKQSHFEMVTNQSCSSGMLSLQTMMNAIQSRYAKNHTAGNIEILQRAKAQLLEFSNLSGDISTESALREFGYLEAVQFQSGTQVSNFLGLEGHWKKSLITKDLLIVGGVCVGAAWMIGEYFFKKSKEVVAFQGYNKRQRQKLKFARARDEKMGHYVEAPDSTLEHYFGSAYTKKGKTKGKTHGMGKKNHRFVNMYGFDPSDYTFIRYVDPLTGYTLDESPYTDIRLIQSQFSDIREQQLLNDELERNMVYHKPGVQGYLVKDKTSQILKIDLTPHIPLKVCDATNNIAGHPDREGELRQTGKGQLLDYAELPQKKELVEFESTSMFRGVRDYNPISSVICQLENESEGRTTQLFGLGFGPFIITNQHLFVRNNGSLTVRSQMGVFKVNSTVTLQMRPVEGRDVLIIKMPKDFPPFPQRLKFRQPTHSEKVCLILTNFQQKSSSSMVSETSHIIPKENTYFWKHWISTKEGHCGSPIVSTTDGAILGIHSLSNMTNTSNYFACFPKGFTETYLATESVHEWVKGWKFNASNVCWGSFHLQDSKPTKEFKTVKLVTDLLGEAVYTQGCDSKWLFNAVHTNIQAVAQLESNLVTKHTVKGKCKLFETYLNVDKAAHDFFSKYMGFYKPSKLNREAYTQDLMKYSKVIQVGEVDCGVFESALTGLLHNLGRWGFTTACYTTDEDSIYAALNMKAAVGALYRGKKRDYFDAMSPSEREHLLFLSCKRLYFGQLGVWNGSLKAELRPKEKVDLNKTRTFTAAPIETLLGGKVCVDDFNNMFYSLHLKAPWSVGMTKFYGTWNQLMCKLPDDWVYCDADGSQFDSSISPYMINAVLRIRLHFMEDWDIGSQMLQNLYTEIVYTPISTPDGTVVKKFKGNNSGQPSTVVDNTLLVVLAMHYALLKSGVPLEEQDSVCVYCVNGDDLLIAIRPDMEHKLDGFQALFSELGLNYEFNSRSKDKKDLWFMSHKAIQCGEILIPKLEEERIVSILEWDRSHEPIHRLEAICASMVESWGYPELTHEIRRFYAWVLEQSPYNALATTGLAPYIAESALKTLYTNVHPTSTELEKYSIQFDEQMDEEDDMVYFQAGTLDADETQAQKSEGRKKEGEGNSSKAVAVKDKDVDLGTAGTHSVPRLKSMTSKLTLPMLKGKSVVNLDHLLSYKPKQVDLSNARATHEQFQNWYDGVMASYELEESSMEIILNGFMVWCIENGTSPDINGVWTMMDDEEQVSYPLKPMLDHAKPSLRQIMRHFSALAEAYIEMRSREKPYMPRYGLQRNLRDQSLARYAFDFYEITATTPIRAKEAHLQMKAAALKNSNTNMFGLDGNVTTSEEDTERHTATDVNRNMHHLLGVKGV",
"proteome": null,
"gene": null,
"go_terms": [
{
"identifier": "GO:0004197",
"name": "cysteine-type endopeptidase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006508",
"name": "proteolysis",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0003676",
"name": "nucleic acid binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0005524",
"name": "ATP binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0008234",
"name": "cysteine-type peptidase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0003968",
"name": "RNA-directed RNA polymerase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0039694",
"name": "viral RNA genome replication",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0005198",
"name": "structural molecule activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0016818",
"name": "hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0018144",
"name": "RNA-protein covalent cross-linking",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0003723",
"name": "RNA binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006351",
"name": "DNA-templated transcription",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0019028",
"name": "viral capsid",
"category": {
"code": "C",
"name": "cellular_component"
}
}
],
"protein_evidence": 3,
"source_database": "unreviewed",
"is_fragment": false,
"in_alphafold": false,
"in_bfvd": false,
"ida_accession": "540c45df77e47beb363c4ab9fa44ae70c9fcb5f4",
"counters": {
"domain_architectures": 3385,
"entries": 44,
"isoforms": 0,
"proteomes": 0,
"sets": 5,
"structures": 0,
"taxa": 1,
"dbEntries": {
"profile": 6,
"cathgene3d": 4,
"smart": 2,
"pfam": 9,
"ssf": 3,
"cdd": 1,
"panther": 1,
"prints": 1,
"interpro": 17
},
"proteome": 0,
"taxonomy": 1,
"similar_proteins": 3385
}
}
}
