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{
    "metadata": {
        "accession": "A0A7N8WW49",
        "id": "A0A7N8WW49_9TELE",
        "source_organism": {
            "taxId": "205130",
            "scientificName": "Mastacembelus armatus",
            "fullName": "Mastacembelus armatus (zig-zag eel)"
        },
        "name": "BTB domain-containing protein",
        "description": [
            "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that regulates the response to oxidative stress by targeting nfe2l2/nrf2 for ubiquitination. Keap1 acts as a key sensor of oxidative and electrophilic stress: in normal conditions, the BCR(KEAP1) complex mediates ubiquitination and degradation of nfe2l2/nrf2, a transcription factor regulating expression of many cytoprotective genes. In response to oxidative stress, different electrophile metabolites trigger non-enzymatic covalent modifications of highly reactive cysteine residues in KEAP1, leading to inactivate the ubiquitin ligase activity of the BCR(KEAP1) complex, promoting nfe2l2/nrf2 nuclear accumulation and expression of phase II detoxifying enzymes"
        ],
        "length": 601,
        "sequence": "MHCPMRKKRPTRDSDFSAIVVPSMHGSGYLDYTVETHASRSLAAMDELRHQEMLCDLVLHVTYKERTVDFKVHRLVLASCSPYFRAMFTSSFKECCASEVTLRDVCPQVVGRLIDFAYTSHITVGEKCVLHVLLGAMRFQMEDVAKACCDFLIKHLEPANVIGISRFAEEIGCTELHQQSREYINTHFREVIKEDEFFSLSHCQLLELISQDSLKVLCESEVYKACTDWVGWDMEGRAQYLHALLNAVHIYALPPKFLKNQLLSCPILSKANSCKDFLSKIFQDMTLRKLSPAPIRGTQLIYVAGGYQHQSLASMEAYDPRKNVWVKLTDMGTPCSGLGACTLFGLFYTVGGRNLSLQNNTESSALCCYNPMTNQWSQRASLNIPRNRVGVGVVDGCIYAVGGSQGSTHHNTVERWDPESNRWSFVCPMSVARLGAGVTACRGVLYVVGGYDGQNRWSTAEKYQPDTNTWYQLAPMSSVRSGLGLVCVNSYLYAVGGYDGRSQLASVERYNIARNIWEPRASMQYCRSAHGVTVHQGRIFVLGGFNQHGFLASIECYCPERNEWTYVTDMPVGRSGMGVAVTMEPCPGSLPEPEEDEDIAT",
        "proteome": "UP000261640",
        "gene": null,
        "go_terms": [
            {
                "identifier": "GO:0005515",
                "name": "protein binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "4b37c4a325da8293423092f75d95e59d23fc139e",
        "counters": {
            "domain_architectures": 3583,
            "entries": 20,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 3,
                "ssf": 2,
                "pfam": 3,
                "profile": 1,
                "smart": 3,
                "pirsf": 1,
                "panther": 1,
                "interpro": 6
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 3583
        }
    }
}