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InterPro-Version: 108.0
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{
"metadata": {
"accession": "A0A7N8WUB2",
"id": "A0A7N8WUB2_9TELE",
"source_organism": {
"taxId": "205130",
"scientificName": "Mastacembelus armatus",
"fullName": "Mastacembelus armatus (zig-zag eel)"
},
"name": "Tumor protein 63 (p63)",
"description": [
"Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes",
"Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression"
],
"length": 570,
"sequence": "MLVLEGSQYTNLGLLNSMDQNIQNGGSTSTSPYNNDHAQNNVTAPSPYAQPSSTFDALSPSPAIPSNTDYAGPHTFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVLTNPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNDGQIAPPSHLIRVEGNSHAQYVEDSITGRQSVLVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQHVTDATKSSEGTKRPFRQVSHGIQMSTIKKRRSTDEEIFCLPIKGREIYEILVKIKESLELMQFLPQHTIESYRQQQQTLLQKQTSVPSQPSFGSSSPTHGKVNKLPSVSQLINPQQRNTLTPSTPFVSAVTPMMGTHIPMNTDMSSLSPTHSLQPQLPLVPSSHCTPPPPYPMDSSISSFLIRLGCAGCLDYFTAQGLTNIYQIENYNMEDLSRLKIPAEFQHIIWKGIMEHRQAMDFSPPPHIVRTTSGASTVSVGSSEARGERVIDAVRFTLRQTISFPPRDEWSDFSFDLDSRRNKQQRIKEEGE",
"proteome": "UP000261640",
"gene": null,
"go_terms": [
{
"identifier": "GO:0003677",
"name": "DNA binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0003700",
"name": "DNA-binding transcription factor activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006355",
"name": "regulation of DNA-templated transcription",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0005634",
"name": "nucleus",
"category": {
"code": "C",
"name": "cellular_component"
}
},
{
"identifier": "GO:0000976",
"name": "transcription cis-regulatory region binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0051262",
"name": "protein tetramerization",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0005515",
"name": "protein binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006915",
"name": "apoptotic process",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"protein_evidence": 3,
"source_database": "unreviewed",
"is_fragment": false,
"in_alphafold": true,
"in_bfvd": false,
"ida_accession": "971a6e93f680f44c0f4c7c1131009890cae28dcd",
"counters": {
"domain_architectures": 2261,
"entries": 25,
"isoforms": 0,
"proteomes": 1,
"sets": 4,
"structures": 0,
"taxa": 1,
"dbEntries": {
"cathgene3d": 3,
"ssf": 3,
"pfam": 3,
"cdd": 2,
"smart": 1,
"panther": 1,
"prosite": 1,
"prints": 1,
"interpro": 10
},
"proteome": 1,
"taxonomy": 1,
"similar_proteins": 2261
}
}
}
