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{
    "metadata": {
        "accession": "A0A7L4CDH4",
        "id": "A0A7L4CDH4_9AVES",
        "source_organism": {
            "taxId": "382315",
            "scientificName": "Nyctiprogne leucopyga",
            "fullName": "Nyctiprogne leucopyga"
        },
        "name": "Cystic fibrosis transmembrane conductance regulator",
        "description": [
            "Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains. The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer"
        ],
        "length": 1480,
        "sequence": "FFNYYFFLLRWTKPILKKGYRRRLELSDIYQIPSADSADNLSEKLEREWDRELATSKKKPKLINALRRCFFWKFMFYGIILYLGEVTKSVQPLLLGRIIASYDPDNSDERSIAYYLGIGLCLLFLVRTLLIHPAIFGLHHIGMQMRIAMFSLIYKKILKLSSRVLDKISTGHLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLLWDMLEASAFSGLAFLIVLAFFQAWLGQMMMKYRNKRAGKINERLVITSEIIENIQSVKAYCWEDAMEKMIESIRETELKLTRKAAYMRYFNSSAFFFSGFFVVFLAVLPYAVIKGIILRKIFTTISFCIVLRMTVTRQFPGSVQTWYDSIGAINKIQDFLLKKEYKALEYNLTTTGVELDKVTAFWDEGIGELFVQANRENNNSKAPSTDNNLFFSNFPLHASPVLHDINFRIEKGQLLAVSGSTGAGKTSLLMLIMGELEPSQGKIKHSGRISFSPQVSWIMPGTIKENIIFGVSYDEYRYKSVIKACQLEEDISKFPEKDYTVLGEGGIILSGGQRARISLARAVYRDADLYLLDSPFGHLDIFTEKEIFESCVCKLMANKTRILVTSKLEHLKIADKILILHEGSCYFYGTFSELQGQRPDFSSELMGFDSFDQFSAERRNSILTETLRRFSIEGEGMGSRNEIKKQSFKQTSDFNDKRKSSIIINPLNANRKFSVMQKNGMQVGVEDGHNDPPERRLSLIPDLEQGDVGLLRSNMLNTDHMLQSRRRQSVLNLMTGTPSVSYGPNVSKKGSTTFRKMSMVPQTNLSSEIDIYTRRLSRDSVLDITDEINEEDLKECFTDDAESMGTVTTWNTYFRYVTIHKNLIFVLILCVTVFLIEVRKPAADVMLLEIMFVQTDVYPKFLNHLQNHNSIQMCSSSYHVSFIFVVIYDKIFALGKFGFHPFIMLSLQTIINLVKEDNFQSVKGYYCFLFTFSVKLNGGMLNRFAKDTAVLDDLLPLTVFDFVQLILIVIGAITVVSILQPYIFLASVPVIAAFIVLRAYFLHTSQQLKQLESEARSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEIIFVVFFVAVAFISIITTGDGPGRVGIILTLAMNIMGTLQWAVNSSIDVDSLMRSVGRIFKFIDMPTEEMKNIKPQKKNQLSDALVIENRHAKEEKNWPSGGQMTVKDLTAKYGEGGAAVLENISFSIDSGQRVGLLGRTGSGKSTLLFAFLRLLNTEGDIQIDGVSWNTVSVQQWRKAFGVIPQKVFIFSGTFRMNLDPYGQWNDEEIWKVAEEVGLKSVIEQFPGQLDFVLVDGGCVLSHGHKQLMCLARSVLSRAKILLLDEPSAHLDPVTSQVIRKTLKHAFANCTVILSEHRLEAMLECQRFLVIEDNKLRQYESIQKLLNEKSSFRQAISHADRLKLLPVHHRNSSKRKPRPKITALQEETEEEVQETRL",
        "proteome": "UP000551823",
        "gene": "Cftr",
        "go_terms": [
            {
                "identifier": "GO:0005524",
                "name": "ATP binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0016020",
                "name": "membrane",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            },
            {
                "identifier": "GO:0140359",
                "name": "ABC-type transporter activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0055085",
                "name": "transmembrane transport",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0016887",
                "name": "ATP hydrolysis activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005254",
                "name": "chloride channel activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006811",
                "name": "monoatomic ion transport",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": true,
        "in_alphafold": false,
        "in_bfvd": false,
        "ida_accession": "0639bdb78bb8aea31a84de8d27883b79320647b7",
        "counters": {
            "domain_architectures": 1366,
            "entries": 27,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 4,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 2,
                "ssf": 2,
                "cdd": 3,
                "profile": 2,
                "pfam": 3,
                "smart": 1,
                "ncbifam": 1,
                "panther": 1,
                "prints": 1,
                "prosite": 1,
                "interpro": 10
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 1366
        }
    }
}