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{
    "metadata": {
        "accession": "A0A6Q2XQL5",
        "id": "A0A6Q2XQL5_ESOLU",
        "source_organism": {
            "taxId": "8010",
            "scientificName": "Esox lucius",
            "fullName": "Esox lucius (Northern pike)"
        },
        "name": "Adenylate cyclase type 8",
        "description": [
            "Catalyzes the formation of cAMP in response to calcium entry leadings to cAMP signaling activation that affect processes suche as synaptic plasticity and insulin secretion. Plays a role in many brain functions, such as learning, memory, drug addiction, and anxiety modulation through regulation of synaptic plasticity by modulating long-term memory and long-term potentiation (LTP) through CREB transcription factor activity modulation. Plays a central role in insulin secretion by controlling glucose homeostasis through glucagon-like peptide 1 and glucose signaling pathway and maintains insulin secretion through calcium-dependent PKA activation leading to vesicle pool replenishment. Also, allows PTGER3 to induce potentiation of PTGER4-mediated PLA2 secretion by switching from a negative to a positive regulation, during the IL1B induced-dedifferentiation of smooth muscle cells",
            "Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling"
        ],
        "length": 1191,
        "sequence": "MELSEVRCSSASEELYTINRTPTSNSSTRPKRLLWQNAVRHITEQRFIHEQSEAKGITPDEPYDQSLRKQSGGRTSVGDRHNNGGTKVFPERASSDLGFLQIDCAPSNSDFFLNWGYTYRGVIFPTLRNSFKSRDLERLYQRYFLGQRRKSVVVMNILDVVTKLTLLVLHLTLASSPMDPIKGMLLGFFTGIEVVICALVVVRKDTTSHSYLQYSGVVTWVVMTTQILAAGLGYGLLGDGVGYVLFTLFATYSMLPLPLTWAILAGLATSALHIVVQLFISANAQLSTNQVVAQAVLFMCMNTAGIFISYLSDRAQRQAFLETRRCIEARLRLETENQRQERLVLSVLPRFVVLEMINDMTNVDDEHLQHQFHRIYIHRYENVSILFADVKGFTNLSTTLSAQELVRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRQDHAHCCVEMGLSMIKTIRYVRSRTKHDIDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKASLDCLNGDYEVEEGHGEDRNEFLRRHNIETYLIKQPEDSLLTLPEDIMKEATSTDRRASSTTFNEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVHSGPEEINKRIESIIDLRSGDKLRREHIKPFSLMFKDSSLEEKYSQMRDEVFKSNLVCAFIVLIFITAIQSLLPSARMVTMVIQFSVLIILHSCLVLLTTAEDYKCLPLVLRKACCWINETYMARNVIVFVSILINFLAAMINIYFVFTGVLAMVTCAVFLRLNSVLKLAVLLVMIAVYSLLTEAFYISLFLRYDHVHHNTENVLGTKETSLLLMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELYSQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEERFQDIEKIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFAIALNESIQEINKHSFNNFELRIGMAHGSVVAGVIGAKKPQYDIWGKTVNLSSRMDSTGVSGKIQVPEDTYLILTERGFAFEYRGEIYVKGISEQEGKIRTHFLHGRVQPNPLILQPRKLQGQYSLAAVVLGLVQSLNRQKQKQILNENNNSGIMKGHHYNRRTLLAQAGPEGGGHADVADKAELP",
        "proteome": "UP000265140",
        "gene": "ADCY8",
        "go_terms": [
            {
                "identifier": "GO:0009190",
                "name": "cyclic nucleotide biosynthetic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0035556",
                "name": "intracellular signal transduction",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0004016",
                "name": "adenylate cyclase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006171",
                "name": "cAMP biosynthetic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0005886",
                "name": "plasma membrane",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            },
            {
                "identifier": "GO:0016849",
                "name": "phosphorus-oxygen lyase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "477ab5fb934d4ba4d65c0403a72a413e8810db5d",
        "counters": {
            "domain_architectures": 7786,
            "entries": 17,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 1,
                "smart": 1,
                "ssf": 1,
                "pfam": 3,
                "cdd": 1,
                "profile": 1,
                "panther": 1,
                "pirsf": 1,
                "prosite": 1,
                "interpro": 6
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 7786
        }
    }
}