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{
    "metadata": {
        "accession": "A0A6P9BBC6",
        "id": "A0A6P9BBC6_PANGU",
        "source_organism": {
            "taxId": "94885",
            "scientificName": "Pantherophis guttatus",
            "fullName": "Pantherophis guttatus (Corn snake)"
        },
        "name": "NF-kappa-B inhibitor zeta",
        "description": [
            "Involved in regulation of NF-kappa-B transcription factor complexes. Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation. Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer. Also seems to activate NF-kappa-B-mediated transcription. In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters. Promotes transcription of LCN2 and DEFB4. Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS. Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling. Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR)"
        ],
        "length": 709,
        "sequence": "MIVDNSRDVGLDGDSGSLNSPFNLAFFYGTSPRSSEGSCSPTPSAPGSPDSDSEPSANGGSGGGGGIYLRKRRYSRNAARPTGEAEQHMGGGKQQRGPFQGVRVKNSVKELLLHLRNSKQMSTDYGTEELKAQGTLMKYDPYTVELKNILTHNRKRKAPDCLSDGVYYKRTAILQPQFLTPPQTPTSMDNNMEDPHNNEPKQDSSCDMLQNIINIKNESSPVSLNTVQVSWLHNMVNPNSPGEHQYQEMAGAPGFSPVQKYQAFQTSSSSPMLELSQNYQFSPTQQQQDMSQHCIPLLEYRPHSAGSHSSEYQQNIYDSQEVPYCTTESFASLLNDSEGPDNISAPLPQAIPSGLQQTEVSSCSQHFNQVSDNTSRGLEEHGLSLSSSDISLQLQSSTGSTSQLGKSFFQWQVEQEENKMANISQDQILAKDSDGDTFLHIAVAQGRRAVSYVLARKMAALHMLDIKEHNGQSALQVAVAANQHLIVQDLVSLGAQVNTTDCWGRTPLHVCAEKGHAQVLQAIQKGAIVSNQYVDLEGTNYEGLTALHCAVVVHNAVVHDLQGQQSPHTPEVQELRLKSKKLADTIKYLIQMGASVEARDRKSGRSALHLAAEEANVELLRLFLELPNCLSFINAKAYNGNTALHVAASLQHRMTQLDAVRLLMRKGADPSARNLENEQPVHLVPDSSVGVEIRRILKGKTSQQRSSVY",
        "proteome": "UP001652622",
        "gene": "NFKBIZ",
        "go_terms": [
            {
                "identifier": "GO:0003677",
                "name": "DNA binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0070974",
                "name": "POU domain binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005515",
                "name": "protein binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "19028327281c6137a19c9e0fe43f5e35bbb621f2",
        "counters": {
            "domain_architectures": 42283,
            "entries": 12,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 1,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "profile": 3,
                "cathgene3d": 1,
                "smart": 1,
                "ssf": 1,
                "pfam": 1,
                "panther": 1,
                "prints": 1,
                "interpro": 3
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 42283
        }
    }
}