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{
    "metadata": {
        "accession": "A0A6P8RP56",
        "id": "A0A6P8RP56_GEOSA",
        "source_organism": {
            "taxId": "260995",
            "scientificName": "Geotrypetes seraphini",
            "fullName": "Geotrypetes seraphini (Gaboon caecilian)"
        },
        "name": "Fibroblast growth factor receptor",
        "description": [
            "Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway"
        ],
        "length": 815,
        "sequence": "MSEAAALGTRTRACPGSSRGMIAVWCALCFSLVTARLDESLSPKPADYLTSEATFLEDLVLGTGDTIELSCSTRSSSMPVQWFKDGIGVLLTNRTHVGQRLLKIINVSYDDSGMYSCKFWQSHETLNNFTVRVTDSPSSGDDEDDEESEDAGAPYWTRPDKMDRKLLAVPAANTVRFKCPAAGNPTPSIYWLKNGKEFKGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKYGSIRQTYQLDVLERSPHRPILQAGLPANQTAVVGSDVEFHCKVFSDAQPHIQWLKHVEVNGSKNGPDGTPYVTVLKTAGVNTTDKELEVLCLRNITFEDAGEYTCLAGNSIGFSHHSAWLTVLPAEQIEKYDAPGSVSVGILSSVAVFIVCILIIVIVIRYRMKTLSKKAMNMPTVQKISKFPLKRQVTVSLESNSSTNSNSPLVRINRLSSDGPMLANVLELELPADPKWELPRSRLTMGKPLGEGCFGQVVMAEAIGIDKEKPNRAITVAVKMLKDDAIEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLRARRPPGMDYSFDTCKVPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTDDNVMKIADFGLARDVHNIDYYKKTTNGRLPVKWMAPEALFDRVYNHLSDVWSFGVLLWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHELYMIMRECWHAVPSQRPNFKQLVEDLDRVLSVTSVDEYLDLSVPFEQYSPGCPDSHSSSSLGDDSVFGHDLLPEEPCLPKHQPYNGIIQT",
        "proteome": "UP000515159",
        "gene": "FGFR3",
        "go_terms": [
            {
                "identifier": "GO:0004672",
                "name": "protein kinase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006468",
                "name": "protein phosphorylation",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0004713",
                "name": "protein tyrosine kinase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005524",
                "name": "ATP binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005007",
                "name": "fibroblast growth factor receptor activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0008284",
                "name": "positive regulation of cell population proliferation",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0008543",
                "name": "fibroblast growth factor receptor signaling pathway",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0016020",
                "name": "membrane",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "93c526819d6fbfadd394a92fe2489a79b9102caa",
        "counters": {
            "domain_architectures": 918,
            "entries": 35,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 4,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "profile": 2,
                "cathgene3d": 4,
                "ssf": 2,
                "smart": 3,
                "pfam": 3,
                "cdd": 2,
                "pirsf": 1,
                "panther": 1,
                "prosite": 2,
                "prints": 1,
                "interpro": 14
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 918
        }
    }
}