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{
    "metadata": {
        "accession": "A0A6P6BYH0",
        "id": "A0A6P6BYH0_PTEVA",
        "source_organism": {
            "taxId": "132908",
            "scientificName": "Pteropus vampyrus",
            "fullName": "Pteropus vampyrus (Large flying fox)"
        },
        "name": "Endonuclease 8-like 1",
        "description": [
            "Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC"
        ],
        "length": 389,
        "sequence": "MPEGPELHLASHFVNEACRDLVFSGCVEKSPISRNPEVPFESSAYHISALARGKELRLTLSPLPGAQPLREPLALVFRFGMSGSFQLAPSDALPPHAHLRFYTAPPSPGLALCFVDIRRFGHWELGGKWQPGRGPCVLLEYEQFRENVLRNLVDKAFDRPICEALLDQRFFNGIGNYLRAEILYRLKIPPFEKARTVLEALQQRRPSPELTLSQKIRAKLQNPDLLELCHSVPKEVVQLGGKGYGQESGEDDYAAFRAWLQCYGMAGMSSLRDRHGRTIWFQGDPGPLAPKGGRPHKKKSKGAQQSPEDKMENPPPPSKAPSKTRRARRGLPEQTTAQQPKRTSLQQDPGVSPVTEKGKRRGRQASGFCRPQRIKADTSSLETEGTSAS",
        "proteome": "UP000515202",
        "gene": "NEIL1",
        "go_terms": [
            {
                "identifier": "GO:0003906",
                "name": "DNA-(apurinic or apyrimidinic site) endonuclease activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0008270",
                "name": "zinc ion binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0019104",
                "name": "DNA N-glycosylase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006284",
                "name": "base-excision repair",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0003676",
                "name": "nucleic acid binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0003684",
                "name": "damaged DNA binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0016799",
                "name": "hydrolase activity, hydrolyzing N-glycosyl compounds",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "a3c48f027a33489e7a21b1cb4e22b7d0c8aee9f7",
        "counters": {
            "domain_architectures": 875,
            "entries": 16,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 0,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "pfam": 2,
                "cathgene3d": 2,
                "profile": 1,
                "smart": 2,
                "ssf": 3,
                "panther": 1,
                "interpro": 5
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 875
        }
    }
}