General Handler

HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept

{
    "metadata": {
        "accession": "A0A6J3DSX6",
        "id": "A0A6J3DSX6_AYTFU",
        "source_organism": {
            "taxId": "219594",
            "scientificName": "Aythya fuligula",
            "fullName": "Aythya fuligula (Tufted duck)"
        },
        "name": "E3 ubiquitin-protein ligase XIAP",
        "description": [
            "Multi-functional protein which regulates not only caspases and apoptosis, but also acts as an E3 ubiquitin-protein ligase mediating ubiquitination and subsequent proteasomal degradation of its target proteins. Acts as a direct caspase inhibitor. E3 ubiquitin-protein ligase that acts as an important regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of ripk2 downstream of NOD1 and NOD2, thereby transforming ripk2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling. A key apoptotic suppressor in eggs. Acts as a positive regulator of Wnt signaling"
        ],
        "length": 493,
        "sequence": "MTCNGPGNSEPHATPGTDYDQDWAQEHHRLGSFAEFPLDCLVSASALAQAGFVYTGEGCKVKCFSCHVTIEGWQPGDSAVERHKNLSPNCKFITESTFLENDLRPLAQNYQHRAENGSSNSVLLPALDDSPELEADYLLRTRQVVDMSDILYPKNPAMCSEEARLKSFHNWPSYGLLAPKELASAGLYYTGVGDQVACFCCGGKLKNWEPSDRAWSEHKRHYPRCYFVLGRDVGNVPSESIPAELGRNGLNDEQHPRNPSMAEYERRIQTFLNWIYPVNKEQLAEAGFYSIGNGDHVVCFHCGGGLQEWKENEDPWDQHAKWFPGCRFVREEKGLEFINNVHLGGGCRDSTIEAAEVTVLPKDDHLQNHLVQNAIHMGFSLSEIKSIMQKKLQMSGASYTSVEDLVADLISAQKENLKEEIPNENPLDQDLSMEEKLRRLQEEKLCKICMAKDISVVLIPCGHLVACKECAEAVNVCPLCCTNILKRQKIFMY",
        "proteome": "UP000504639",
        "gene": "XIAP",
        "go_terms": null,
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "24cd8ffd9fbb9912c7fdde133e9845921a373549",
        "counters": {
            "domain_architectures": 556,
            "entries": 20,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 5,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 3,
                "ssf": 1,
                "smart": 2,
                "cdd": 2,
                "pfam": 3,
                "profile": 2,
                "panther": 1,
                "prosite": 1,
                "interpro": 5
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 556
        }
    }
}