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{
    "metadata": {
        "accession": "A0A6J3CP50",
        "id": "A0A6J3CP50_AYTFU",
        "source_organism": {
            "taxId": "219594",
            "scientificName": "Aythya fuligula",
            "fullName": "Aythya fuligula (Tufted duck)"
        },
        "name": "Desmoplakin",
        "description": [
            "Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance"
        ],
        "length": 2263,
        "sequence": "MSMNGGSHPRLNTLGRMARADSGTDLRYEMSSHVVSGGGGGTHTHKTYYYQKTYGGDYASDGYGQNGTCTVSRRQNTIQELLQNCSDCLMRAELIVQPELKYGDGVQIRGNRDLEECFAQANDQMDILDGLIRELRQMNQPCEMYQKRLLQLQEQMRALYKAISVPRARRASSKGGGCYSSQSGSGWDEYTKRVTSECLNWMRQQKSEMELVKWGFDAASIEQQISDHRRTHNAIGDYRWHLDKVKTDLREKAAVHQLEEEYEGLLKYSFERMDQLRQFQNLIQATSREIMWINDCEEEELLYDWSDRNTDIARKQEAFSKRMSELELKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQATECYLKNLQDSIRKKFMCDKSMSLQCLLEQIKELENERERILEYKRQVQSLVNKSKKIVQLKPRNPDYRSNKPIILKALCDYKQDLKTVRKGDECILKDNNERSKWLVTGPGGVDMLVPSVSLIIPPPNPLAVDLATKIEQYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRKEDYQKIITDLEIHYQEFLRNSQGSEMFGDEDKRKMQTQFTDAQKHYQTLIIQLPNQPRQPQPVIPTETCPVGSSNTIIVNERNREHDKQEAWLLMELQKLRRQIESSEIRMVQRAPLGVDQGALHDFSVRIQELEGVQNDSQIMAETLNKHKDLLPNFRGCEKYVYLQSEINALFQKLENINGVSAGYLDSLNVLRCLLQLILQTEDVIRVFEVRLSEEETVPLDLDKVEAYRACLKKMKADLNMKKSLLNALENELQKMLQIHSQSCQSYTLYDMDIGKFSDKVTQLIDRWQRAEKQIDNRSWDLERQIKQLKTYRDLYQALCKWICDAKRRQDSIESMKLCDSNTIMRYLHDQKNLHSEICGKRDKVEELLKHADQCSAAIKDYELQVASYSSGLETLLNIPIKKCVVQSPAVLILQEASEAQARYIELLTRSGDYYKFLSEMLKSMEDLKMKATKIELLEEELRLARDSNSETNNKHKFLEQNLQKYQMDISQLKAKLMSLEEMKRQAEMDGNSAKQNLDKCYAQIKDLNDRITRLTYETEDEKRKRKLLEDRYEQQKNDYDQLQKTRQNEKDSLGWQKLESEKVIKEKEYEIERLRVLLQDEGTRKREYENELAKASNRIQESKNQYSHIMQERETLLIKMSALEQDKARLQRLEEELNRLKVSLESESRLKQRLESEKQQILNDLNQWKSQHSRTEESIRKIQCEREKSEREKNTLRTEIERLQMEIKRIEERYRCRLEETAVKNQSELESERLRLQREIEKLKQRPYGSHRSTQTEEDFCIDASKLLFSGLRKKITAMQLYECQIIDKVTLDKLLKGQRSVEEVAADIEPYLKGAGAIAGVSVLPRQKYSFVEAKRNQLLTAENAVLLLEAQAATGGVIDPHRNEVLTVDSAIARDLIDFDDREQIYTAEKAITGFKDPFSGKTVPLSEAIKKNLVDRETGIRLLEAQLAVGGIVDPVNSVFLPKDIALSRGLIDKDLYRILNNCQSATKNFIDPTTKKAVTYMQLKEKCRIEPHTGLLLLPVQKRSMSFQGIRQPVSADALLEAGIIKESTRNDLERGAITVEEVSERIIDFLQGSSCIAGIYNEATKEKLGIYQAMKIGLVRPGTALELLEAQAATGFIVDPVSNVRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYKDPETGNIISLFQAMNKELIERGHGIRLLEAQIATGGIIDPKESYRLPVETAYKRGYFNEELNQILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEATGLCLLPLREKKKVVHTSQKNTLRKRRVVIVDPETNREMSVQEAYSKGLIDYDTYTELAEQECEWEEITITGSDGSSRVVLVDRKTGSQYDIQDAIDKGLVERKFFDQYRSGSLSLTQFADMISCRNGTDEVFRHESVTRSPTVLSVRSSSSMIRSGSFSETTEECSPIAAIFDTENLEKISISEAIQRGIVDSITGQRLLEAQACTGGIICPTTGQRLSLQEATSQGIVDQDMATRLKPAQKAFLGFEGIKGGRKRMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVRGRISTEEAIRNGLIDGRAAQKLQDTNSYPKILTCPKTKLKISYKDAMNRSMVEDITGLKLLEAASVSSKGISSPYNVSSAPGSRSGSRSGSRSGSRSGSRRGSFDASATSSYSYSYSTFSSGSIGR",
        "proteome": "UP000504639",
        "gene": "DSP",
        "go_terms": [
            {
                "identifier": "GO:0005515",
                "name": "protein binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005856",
                "name": "cytoskeleton",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            },
            {
                "identifier": "GO:0045104",
                "name": "intermediate filament cytoskeleton organization",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": false,
        "in_bfvd": false,
        "ida_accession": "357cdbaead1c2edeeb3dccdb6fecfb8a8b48eea2",
        "counters": {
            "domain_architectures": 506,
            "entries": 24,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 3,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 5,
                "cdd": 1,
                "ssf": 2,
                "pfam": 6,
                "profile": 1,
                "smart": 1,
                "panther": 1,
                "interpro": 7
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 506
        }
    }
}