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{
    "metadata": {
        "accession": "A0A6J2VFZ3",
        "id": "A0A6J2VFZ3_CHACN",
        "source_organism": {
            "taxId": "29144",
            "scientificName": "Chanos chanos",
            "fullName": "Chanos chanos (Milkfish)"
        },
        "name": "Ryanodine receptor 2",
        "description": null,
        "length": 4963,
        "sequence": "MAEGGEGEDEIQFLRTDDEVVLQCSATVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPPDLSICTFVLEQSLSVRALQEMLANTEEKAEGRVDVEKWKFMMKTAQGGGHRTLLYGHAVLLRHSYSGMYLCCLSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPICSGSEVAQGYLIGGDVLRLLHGHMDECLTVPSGEHGEEQRRTVHYEGGAVSSHARSLWRLETLRVAWSGSHTRWGQPFRLRHVTTGKYLSLTDDKGLLLMDKEKADVKSTAFCFRSSKEKLDSGFKKEVDGMGVADIKYGDSVCYIQHVDTGLWLTYQSVDAKCARMGGVQRKAIMHHEGHMDDGLTLSRSQHEESRTARVIRSTVFLFNRFIRGLDALSKKGKTSTLDLPIESVSLSLQDLIGYFQPPDEHLEHEDKQNRLRALKNRQNLFQEEGMINLVLECIDRLHVYSSAAHFAEVAGREAGETWKSILNSLYELLAALIRGNRKNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLDVLCSLCVCHGVAVRSNQNLICDNLLPGRDLLLQTRLVNHISSMRPNIFLGVSEGSAQYRKWYYELIVDHVEPFVTAEATHLRVGWASTPGYSPYPGGGEGWGGNGVGDDLYSYGFDGLHLWSGCIARTVSSPNQHLLRMEDVVSCCLDLSAPSISFRINGQPVQGMFENFNSDSLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPPGYAPCFEAVLPREKLRVEHSQEYKHDHSSTRDLLGPTITLTQAAFTPTPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWTYGTIRDDNKRQHPCLVEFSKLPEQERSYNLQMSLETLKTLMALGCHVGLADEHAVEKVKNLKLSVKYELSSGYKPAPMDLSHIKLASTQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDVKNKRNPRLVPYALLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAARTDISNMSAERFRIFRAEKSYSVNSGKWYFEFEVVTAGEMRVGWARPGCLPDRELGSDEHAFVFDGFKAQRWHQGNEHFGRSWQAGEVVGCMVDMNEHTMVFTLNGEVLLDDSGSELAFKDFEVWEGFIPVCSLGVCQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNMNRDITMWLSKRLPQFIPVPPNHEHIEVTRIDGTVESSPCLKVTQRSFGSQNSSTDIMFYRLSMPIECAESFAKSPGSKLPSNGSFFSPKKDLEDFETVSDFEVLMKSAHGHMSSNGPEKEKDEFNNHKDYNQEKPSKLKQRFMLKRTKPDLNSSQSSARLSQEVLADERDDYEFLMQTATYYYSVRIFPGQEPSSVWVGWVTSDFHQYDPAFELSKVRTVTVTLGDEKGKVHESVMRSNCYMVWAGESTSPGQGRNNTGLEIGCVVDTASGLLTFTSNGKELSTYYQVEPSTKLFPAVFAQATSPSVFQFELGRIKNVMPLSAGLFKSERKNPNPQCPPRLHIQFLTPVLWSRVPNHFLKAEVTRVSERHGWLVHCSEPLQFMSLHIPEENRSVDILELTEQRELLKFHYHTLRLYSAVCALGNNRVAHALCSHVDEAQLLSAIQNKYMPGLLRTGYYDLLIDIHLSSYATARLMMNSEYIVPMTEETKSITLFPDEKKKHGLPGIGLSTSLRPRMRFSSPCFVSGVAGGNGADFFQYSPEFPLETLKSRTMEMLTEAVQEGSLHVRDPIGGSTEFLFVPLIKLFYTLLIMGIFHNGDLRTILQLIEPSVFSQDSGSESAPHRPQGDTKQSEGQGSGMVEERLKGKLPKEGLLQMKLPEPVKLQMCHLLQYLCDCQVRHRIEAVVAFSDDFVANLQENQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINMLLNFKDGNQDCPCPEDIRDQLINFHEDLMTHCGIEMDDDKAGDADGDFTLRGRLMSLVEKVAYLKKKMADLPKKKKTKKPSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGQVRALPKTYTINSVSVEDTINLLASLGQIRSLLSVRMGREEEKLMIRGLGDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLGGGESKEITFPKMVANCCRFLCYFCRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCSMLVSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGEGGNGLLAAMEEAIKISEDPSRDGPSPTSESSRTLDMLEDEEDDTIHMGNAIMTFYAALIDLLGRCAPEMHLINAGKGEAIRIRAILRSLIPIEDLEGVISIPFPMPTLAKDGSVIEPDMSAGFCPDHKAAMVLFLDRVYGIEDQNFLLHLLEVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTKCAPLFAGTEPFASLIDSLLHTVYRLSKGCCLTKAQRDAIEECLLAVCGKLRPSMMQHLLRRLVFDVPLLNEHTKMPLKLLTNHYERCWKYYCLSGGWGSFGAASDEELHLTRKLFWGIFDALARKRYDLELFKLALPCLSAVAGALPPDYMESNYVAMMEKQSSMDAEGNFNPQPADTSNITIPEKLDHFINKYAEHSHEKWSMDKFANGWVHGEQFCESSKVHPLLKPYKGLSEKDKELYRWPIRESLKTMLSWGWSIERTRESDPASLHNRTRRISLSSQLSIEGAHGFSPRPVDMSNVTLSRDLHSMAELLAENYHNIWAKKKKMELEAKGGGSHPLLVPYDTLTAKEKSKDREKAQDILKFFQINGYTVSRAMKEQELDTPSIEKRFAYTFLQQLITYVDEAHEHMLEFDVSTRPKGEKIPHEQQMKFFGKVVLPLVDQYFKNHRLYFLSTAVRPISSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGLDSVKAALRAFFDNAAEDLERTIENLKQGQFTHTRTQPKGVTQIINYTTVALLPVLSSLFEHIGQNLFGEDLILDDVQVSCYRILNSLYALGTSKSIYVERQRPALGECLAAFSGAFPVAFLEPHLNRHNSYSIYNTKNSRDRAALGLPAQVGEVCALIPSLEKSLEEIMELAESGMRYTQMPHVMEVVLPMLCSYMSHWWEHGPENNPDRAESCCTSLTSQHMNALLGNILKIIYNNLGIDEGAWMKRLAVFSQPIISKAQPQLLKTHFLPLMEKLKKKAATVLVDEEHMKAEGRGEMSESELLILDEFTILVRDLYAFYPLLIRFVDYNRAKWLKEPNPEAEELFRMVAEVFIFWAKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKGAVSDQERKKMKRKGDRYSMQTSLIVAALKRLLPVGLNICAPGDQELIALAKNRFTQKDTEDEVREIIRNNLHLQGKLEDPAIRWQMALYKDMPNRSEDTSDPEKTVERVLDIAHVLFHLDQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGGEEPSEEEEGLKHIDPLHQLIQLFSRTALTEKCKLEEDNLYMAYADIMAKSCHDEEDEEGEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVASTLKLGIAILNGGNSTVQQKMLDYLKDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAISVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENELLDYEEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDTRLQTFLELAESVLNYFQPYLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQMSDAGERSASKEESEREKPEEESPEMGFFSVTTLRTALLALRYNVMLLMKVLSMKSLKKQVKKAKKMTVKDMVTTLLSFYWSVLLGLLHFAFSVARGFFRIVYNSFLGGSLVEGAKTMKVSELLANMPDPTQDEVRGEAGEEGDKKPAEKASAEEDLADLAVATDDMDLLSDIFGLDLRREGGQFKLMPHNPNASLTDLLNTPVPPAPSPSPELRRRQTKSSSEEEKQGVEETNSVPEKAEGEKEEKMEKKKTEKPKKKVRQHRSSKSDEPDLQESAFWKKIIAYQRKLLSYFARNFYNMRMLALFVAFAINFILLFYKVSTSSAVVEEKEVAYSSSSDDSIQWESTDGASVRPVTVHFVLEESSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRISELLGMDKAALDFSDAHEKKKPKKDSSLAAVLNSIDVKYQIWKLGVVFTDNSFLYLAWYMTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGESPDMKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFVMYLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN",
        "proteome": "UP000504632",
        "gene": "ryr2a",
        "go_terms": [
            {
                "identifier": "GO:0005262",
                "name": "calcium channel activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0070588",
                "name": "calcium ion transmembrane transport",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0016020",
                "name": "membrane",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            },
            {
                "identifier": "GO:0005515",
                "name": "protein binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005509",
                "name": "calcium ion binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006816",
                "name": "calcium ion transport",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0005219",
                "name": "ryanodine-sensitive calcium-release channel activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006874",
                "name": "intracellular calcium ion homeostasis",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0005216",
                "name": "monoatomic ion channel activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006811",
                "name": "monoatomic ion transport",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0055085",
                "name": "transmembrane transport",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": false,
        "in_bfvd": false,
        "ida_accession": "bd4cb95c986db5d9a1b2e505c636380224d8cc87",
        "counters": {
            "domain_architectures": 1088,
            "entries": 53,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 6,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 7,
                "pfam": 10,
                "profile": 3,
                "smart": 2,
                "ssf": 4,
                "cdd": 4,
                "panther": 1,
                "prints": 1,
                "interpro": 21
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 1088
        }
    }
}