General Handler

HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept

{
    "metadata": {
        "accession": "A0A672GLM7",
        "id": "A0A672GLM7_SALFA",
        "source_organism": {
            "taxId": "181472",
            "scientificName": "Salarias fasciatus",
            "fullName": "Salarias fasciatus (Jewelled blenny)"
        },
        "name": "Cellular tumor antigen p53",
        "description": [
            "Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Negatively regulates cell division by controlling expression of a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression"
        ],
        "length": 572,
        "sequence": "MLYLETGTTTSYSESQYTNLGLLNSMDQNIQNGGSTSTSPYNNDHAQNNVTAPSPYAQPSSTFDALSPSPAIPSNTDYAGPHTFDVSFQQSSTAKSATWTYSTDLKKLYCQIAKTCPIQIKVLTTPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNDGQIAPPSHLIRVEGNNHSQYVEDSITGRQSVLVPYEPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQHVTDATKSSEAFRQVSHGIQMSTIKKRRSTDEEVFCLPIKGREIYEILVKIKESLELMQFLPQHTIESYRQQQQNLLQKQTSMPSQPSFGSSSPTHGKVNKLPSVSQLINPQQRNSLTPSSMSGGLTDMTPMMGSHIPMNADMSSLSPTHALQPQLPLVPSSHCTPPPPYPMDSSISSFLIRLGCAGCLDYFTAQGLTNIYQIENYNMEDLSRLKIPAEFQHIIWKGIMEHRQAMDFSPPPHIVRTTSGASTVSEARGERVIDAVRFTLRQTISFPPRDDWSDFSFDLDSRRNKQQRIKEEGE",
        "proteome": "UP000472267",
        "gene": "tp63",
        "go_terms": [
            {
                "identifier": "GO:0003677",
                "name": "DNA binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0003700",
                "name": "DNA-binding transcription factor activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006355",
                "name": "regulation of DNA-templated transcription",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0005634",
                "name": "nucleus",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            },
            {
                "identifier": "GO:0000976",
                "name": "transcription cis-regulatory region binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0051262",
                "name": "protein tetramerization",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0005515",
                "name": "protein binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006915",
                "name": "apoptotic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "971a6e93f680f44c0f4c7c1131009890cae28dcd",
        "counters": {
            "domain_architectures": 2261,
            "entries": 23,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 3,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 3,
                "ssf": 3,
                "pfam": 3,
                "cdd": 1,
                "smart": 1,
                "panther": 1,
                "prosite": 1,
                "prints": 1,
                "interpro": 9
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 2261
        }
    }
}