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{
    "metadata": {
        "accession": "A0A665W4W8",
        "id": "A0A665W4W8_ECHNA",
        "source_organism": {
            "taxId": "173247",
            "scientificName": "Echeneis naucrates",
            "fullName": "Echeneis naucrates (Live sharksucker)"
        },
        "name": "7-dehydrocholesterol reductase",
        "description": [
            "Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core. Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta(24)-sterol reductase (DHCR24) to cholesterol. Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation"
        ],
        "length": 478,
        "sequence": "MNSAVAMEATRRRTRAGADGKTSKQMEQTAQWGRAWEVDWFSLISVICLLCFAPFIVFYFVMACDQYQCSISQPVLDLYRGDTTLLSIWSRAPSFTWSAAKIYAIWVAFQAFLYMCIPDALHRLIPGYVGGVQDGARTPAGLINKYEINGLQCWIITHALWFANAHYFHWFSPTIIFDNWIPLMWCANILGYAVSTFAFLKAYLFPTNSEDCKFTGNIFYNYMMGIEFNPRIGKWFDFKLFFNGRPGIVAWTLINLSYMAKQQELYGQVTNSMILVNVLQGIYVLDFFWNEAWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSDAHALAVLSLGLVGYYIFRSTNHQKDLFRRTQGSCSIWGHKPTYIDCSYRSADGSMHHSKLMTSGFWGMARHFNYTGDLMGSFAYCAACGFGHILPYFYIVYMTILLVHRCVRDEHRCSSKYGKDWRRYTDAVPYRLIPAVF",
        "proteome": "UP000472264",
        "gene": "dhcr7",
        "go_terms": [
            {
                "identifier": "GO:0016628",
                "name": "oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0016126",
                "name": "sterol biosynthetic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0016020",
                "name": "membrane",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "9a69035bc8c6d4031bf06ea0caf3992496028c64",
        "counters": {
            "domain_architectures": 10044,
            "entries": 7,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 1,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 1,
                "pfam": 1,
                "panther": 1,
                "prosite": 2,
                "interpro": 2
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 10044
        }
    }
}