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{
"metadata": {
"accession": "A0A5N6ZLP8",
"id": "A0A5N6ZLP8_9EURO",
"source_organism": {
"taxId": "61420",
"scientificName": "Aspergillus caelatus",
"fullName": "Aspergillus caelatus"
},
"name": "Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase",
"description": [
"Multifunctional protein that encodes the first 2 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5) and aspartate transcarbamylase (ATCase; EC 2.1.3.2). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate"
],
"length": 2255,
"sequence": "MPHSAGHEEVALPSSPLTGGAVSYNQINKELQPLPSMDLSSGAVIPPASSRVRGGSGKLFALELEDGTVYQGYSFGAEKSVAGELVFQTGMVGYPESVTDPSYRGQILVVTFPLVGNYGVPSRETMDELLKTLPKYFESTEIHIAALVVATYAGEDYSHFLAESSLGQWLKEQGVPAMHGVDTRALTKRIRQKGSMLGRMLLQKSDETLEEAPVDKDSWRSYFEQTEWVDPNKKNLVDEVSIREPRLFSPPENVALKHPSGRPVRVLCLDVGLKFNQLRCLLARGVEVLVVPWDYDFPTLAGKDYDGLFVSNGPGDPATMTTTVNNLSKTLKEARTPVFGICLGHQLIARSVGAQTLKMKFGNRGHNIPCTSMVTGKCHITSQNHGYAVDSTSLPEDWEELFVNANDGSNEGIRHTSRPFFSVQFHPESTPGPRDTEYLFDVFINSIKDTLTSPEAIKKPVTFPGGTVAENVKASPRVSVKKVLILGSGGLSIGQAGEFDYSGSQAIKALKEEGIYTILINPNIATIQTSKGLADKVYFLPVNADFVRKVIKHERPDAIYVTFGGQTALQVGIQLKDEFESLGVKVLGTPIDTIITTEDRELFARSMDSINEKCAKSASASNLEEALRVVETIKFPVIVRAAYALGGLGSGFANNMDELKDLCTKAFAASPQVLIEKSMKGWKEIEYEVVRDARDNCITVCNMENFDPLGIHTGDSIVVAPSQTLSDEDYNMLRTTAVNVIRHLGVVGECNIQYALNPFSKEYCIIEVNARLSRSSALASKATGYPLAFIAAKLGLGIPLNEIKNSVTKVTCACFEPSLDYCVVKIPRWDLKKFTRVSTQLGSSMKSVGEVMSIGRTFEEAIQKAIRSVDFHNLGFNETSALMSIKGELQTPSDQRLFAIANAMAAGYSVDDIWKLTQIDKWFLSRLKGLSDFGKLMTTYNATTVPRPLIRQAKQLGFSDRQLAKFISSNELAVRRMRVEAGIIPIVKQIDTVAAEFPSVTNYLYLTYNASEHDVAFNDKGIMVLGSGVYRIGSSVEFDWCSVRTIRTLREQGYKTVMVNYNPETVSTDYDEADRLYFENINLETVLDIYQLESSSGVIMSMGGQTPNNIALPLHRLNVRILGTSPEMIDGAENRYKFSRMLDRIGVDQPAWKELTSIEEATSFCDKVGYPVLVRPSYVLSGAAMNTVYSEHDLASYLNQAAEVSREHPVVITKYIENAKEIEMDAVALNGTMVGHFISEHVENAGVHSGDATLILPPQDLDPETVRRIEEATRKIGNALNVTGPYNIQFIAKDNDIKVIECNVRASRSFPFVSKVMGVDLIEMATKAMLGVPFQEYPPVSVPKDYVGVKVPQFSFSRLSGADPVLGVEMASTGEVASFGRDKYEAYLKALLSTGFRLPKRNVLFSIGSYKEKLEMLPSIRKLHQIGFNLFATSGTADFLKENGVPVKYLEILPGQEDELKSEYSLTQHLSNNLIDLYINLPSSNRFRRPANYMSKGYRTRRMAVDYQTPLVTNVKNAKILIEAIARHYDLAVQTIDYQTSHRTVTLPGLINIAAFVPGLMTPGSKDFELVTKASMAAGFSMVRVMPVGTDASVTDARALKVAQQNAQNASFCDFNFSVVATSTNAEQIGQVTGDVGSLFIPFNHLSGNISKVAAVTSHFGSWPSSKPIITDAKSTDLASVLLLASLHSRNIHVMSVSSKEDITLIALSKEKGLKVTCDVSVFSLFLSQEDYPECSFLPSAEDQKALWENLSTIDVFSIGSIPFQLAGEKASPEVGIAETLPLLFTAVSEGRLTVQDIIARLYENPKKIFELHDQVDCSVEVEVDRPYLFQNAHAWSPISGKSVRGSVQRVTFQGKTSCLDGEITPDAPKGTDMSAHRIVPASPSVKAMSPLVQARPEGIDGRLSVAGTPARPSRRALDQAPAVGELGPPLYPTVSQTSSPLHEMLSRSTFRQKHVLSVGQFTRADLHLLFTVAQEMRLGVQRQGVLDVLKGRVLCTLFYEPSTRTSASFDAAMQRLGGRTIAISTEHSSTKKGETLQDTLRTLGCYGDAVVLRHPDPTSTEIAAKFSPVPVVNGGNGSVEHPTQAFLDLFTIREELGTVTGLTITFTGDLRYGRTVHSLIKLLQFYDVRVQLVAPKDLSLPEEVRQQVIASGQLVVESEELTPEIVARSDVLYSTRVQKERFADLEQYERLKNSFVIDNALLKHAKSHMVVMHPLPRNAEIAEEVDFDQRAAYFRQMRYGLYCRMALLALILAP",
"proteome": "UP000326268",
"gene": "BDV27DRAFT_67858",
"go_terms": [
{
"identifier": "GO:0005524",
"name": "ATP binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0046872",
"name": "metal ion binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0016597",
"name": "amino acid binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0016743",
"name": "carboxyl- or carbamoyltransferase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006520",
"name": "amino acid metabolic process",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0004088",
"name": "carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006207",
"name": "'de novo' pyrimidine nucleobase biosynthetic process",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0006541",
"name": "glutamine metabolic process",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0004070",
"name": "aspartate carbamoyltransferase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
}
],
"protein_evidence": 3,
"source_database": "unreviewed",
"is_fragment": false,
"in_alphafold": false,
"in_bfvd": false,
"ida_accession": "85fa9a826e689821908e0bba5db3029bcacfb1bc",
"counters": {
"domain_architectures": 1597,
"entries": 73,
"isoforms": 0,
"proteomes": 1,
"sets": 7,
"structures": 0,
"taxa": 1,
"dbEntries": {
"smart": 3,
"cathgene3d": 9,
"ssf": 8,
"pfam": 8,
"profile": 3,
"cdd": 2,
"hamap": 2,
"ncbifam": 7,
"panther": 1,
"prints": 4,
"prosite": 3,
"interpro": 23
},
"proteome": 1,
"taxonomy": 1,
"similar_proteins": 1597
}
}
}
