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{
    "metadata": {
        "accession": "A0A5E4CEU5",
        "id": "A0A5E4CEU5_MARMO",
        "source_organism": {
            "taxId": "9995",
            "scientificName": "Marmota monax",
            "fullName": "Marmota monax (Woodchuck)"
        },
        "name": "TIR domain-containing adapter molecule 1",
        "description": [
            "Involved in innate immunity against invading pathogens. Adapter used by TLR3, TLR4 (through TICAM2) and TLR5 to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TRIF recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Phosphorylation by TBK1 on the pLxIS motif leads to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines"
        ],
        "length": 687,
        "sequence": "MACPGPSLPGAFDLLGAAGQDKLLYLKHKLKTLRPGCRGAGLLHAMVLLTLGQETEARISLEALKEDAAARLVARQWAGADGAEALEEPPDVSWAVARLYHLLAEEQLCPASLRDSAYQAALRAHGSRGDRRLAELQDEARDRCGWDVVRDLSGFQPLCSDLGGLPPSSASPSGTRSLPRPIDSQLDWSQGHSLRSTSSPVSLARSLAISQSPTVPLASPQRSAPGPSKLCQEPQASPGPEPVPTGCQEPEEMSWPPSVDAACSLELADCPVPRLPVAAPAPAPAHPPEPPEAPETSSQVPVQCMEGSAGPEPLPLPTVEATESPGLVKERTPPQLSGEETAPQKSKPSPPPASAPAPTASLPSPLPPTPASASPCPSSFESASSEQKFYNFVVLHARADEQVALRVREKLEALGVPDGATFCEDFQVPGRGELRCLQDAIDHSGFTILLLTSNFNCRLSLHQVSQALMSSFTQHGREDCVVPFLPLESSLEQLGPDTASLLTGLVWLDENSKVFTRKVANTFKPQKLRARKAHWRKEQDVRALREHSQRLEGERRQAAAMGAAYWDSLQSYRAWQSQVDRLQAAFGSHLSFGTRVPHPSQVPLGGQVPWGGPSPLPTWPGCPQSPPWPAGSPAPAFPPPPPAAPPAPGLQPLIIHHAQMVQLGLSNHMWNQRGAQAPEDKTQEEGR",
        "proteome": "UP000335636",
        "gene": "MONAX_5E013350",
        "go_terms": [
            {
                "identifier": "GO:0007165",
                "name": "signal transduction",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0035666",
                "name": "TRIF-dependent toll-like receptor signaling pathway",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "49eb82fa59e72e6d993b097b734c38c0b130d4c2",
        "counters": {
            "domain_architectures": 228,
            "entries": 12,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 0,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "pfam": 2,
                "cathgene3d": 2,
                "ssf": 1,
                "profile": 1,
                "panther": 1,
                "interpro": 5
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 228
        }
    }
}