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{
    "metadata": {
        "accession": "A0A493TW11",
        "id": "A0A493TW11_ANAPP",
        "source_organism": {
            "taxId": "8840",
            "scientificName": "Anas platyrhynchos platyrhynchos",
            "fullName": "Anas platyrhynchos platyrhynchos (Northern mallard)"
        },
        "name": "Histone-lysine N-methyltransferase, H3 lysine-79 specific",
        "description": [
            "Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone",
            "Histone methyltransferase. Methylates 'Lys-79' of histone H3"
        ],
        "length": 1560,
        "sequence": "MLYSSGLLLPEKGRGLKKLVSELRRLLSTSKCVVLAAARPSDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNTTTPTKVQENKDSGAEEEKAGANSVKKPSPSKARKKKLSKKGRKMAGRKRGRPKKMNTANTERKTKKNQTALELLHAQTVSQTSSSSPQDAYKSPHSPYYQLPPKVQRHSSNQLLVTPTPPALQKLLDSFKIQYMQFMAYMKTPQYKASLQQLLEQEKEKNAQLLGTAQQLFTHCQAQKEEIKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLKEQTKQLEKDNSELRNQSLQLLKARCEELKLDWSTLSLENLLKEKQALKNQISEKQKHCLELQISIVELEKSQRQQELMQLKSYTPSDESLSVQLRNKNHLSRDPEADHNRFQLELECSKFPMPPINGMSPELSMNGHATPYEIHNTFSRPSSKQNTPQYTTSHLDQEIVPCTPNHSSRQKADKMTSLSLPDYTRFSPAKIALRRHLNQDHAVNGKATTNEIQRADHVKENGLTYPSPGISNGIKLSPQETRPSSPAALPIAGEKGLRERTSVSNGETITSLPISIPLSTVQPNKLPVSIPLASVVLPSRVEKVRSTPSPVHQNRDSSTLEKQIGASSHNGVSSAAGNKPLALATSGFSYSSGSVAVNGNLTNSPAHLNHSVDQAALDDSGSLFNSVGSRSSTPQHPLLMMQSRNSGQNSPAHQHSTSPRLNGTSQSLVGVLQYADAQKMFAEGTKGDLQSDAAFSDPENEAKRRIIFTISPNTGHVKQSPSNKHSPLPASARLDCGQAHAQDGKKRGRRKRSSTGNLSGNSGVSPKRKSLPTMSGLFTQPSGSPLNINSMVNNINQPLEITAISSPENSLKNSPVPYQDNDQPPVLKKEKPLIQTNGVHYSPLTSDEEQGSEDEHNSTRIERKIATISLESKSPQKTVENGGSLPGRKQAQTNENMNSSKWKSTFSPISDINLTKTTDSPLQSVSSLSQNSLFAFRPSSEDSLAIDAKITAHARKSIAMPSSGADGLSPSTNSTNGFTYNGGLSTDIGLHSFIDGASLPHKASDVTTSNCSLGFQSQRSKDVGISETNPFLNKRQLEGLSGTKGEDLNRSGVKSKEISEISIRTGGSSEKNSLQHNGKVSKGRDRDVEFKNGHNLFISAAVSSGGLLNGKSLSTAVSSAGNPASSVQTHHPFLNTLTTGSQFPLGPMALQANLNSVTNSSVLQSLFNSMPAAASLVHVSSAATRLTNSHTMGNFSPGVTGGTVGGN",
        "proteome": "UP000016666",
        "gene": "DOT1L",
        "go_terms": [
            {
                "identifier": "GO:0031151",
                "name": "histone H3K79 methyltransferase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0051726",
                "name": "regulation of cell cycle",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0031507",
                "name": "heterochromatin formation",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0005634",
                "name": "nucleus",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": false,
        "in_bfvd": false,
        "ida_accession": "072eceed644c5f2af6e249450b7b8920122060a0",
        "counters": {
            "domain_architectures": 6612,
            "entries": 13,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 2,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 2,
                "profile": 1,
                "ssf": 1,
                "pfam": 1,
                "cdd": 2,
                "panther": 1,
                "pirsf": 1,
                "interpro": 4
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 6612
        }
    }
}