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{
    "metadata": {
        "accession": "A0A452EJI7",
        "id": "A0A452EJI7_CAPHI",
        "source_organism": {
            "taxId": "9925",
            "scientificName": "Capra hircus",
            "fullName": "Capra hircus (Goat)"
        },
        "name": "Rho guanine nucleotide exchange factor 28",
        "description": [
            "Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Also functions in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis"
        ],
        "length": 1706,
        "sequence": "MTVCAKFGKNVYLPKDAEFYFIYNGSHQRHIVIAERTEDNVLQSSIPGHGLQETVTVSVCLCSEGYSPVTMGSDSVTYVDNMACRLARLLVTQADRLTASSHQTLLTPFALTAGALPALDEELVLALTHLELPLGWTVLGNSSLEVSLHRESLLHLAVRWGLTKLSQLLLCLPGGAQALTLPNEEGATPLDLALRGGHSKLVEDITNFQGRRSPGFFRVQLSEDASLRYIHSSETLTLTLNHTAEHLLEADIKLFRKYFWDRAFLIKALEDQEATSEKPDMPSSAAETEEEIKNSGCSGSSPRKEDVKRVKSPVVPLNEHEDPDRLDLDRSFDALKKSKHPPFLAAGQLSDMLNGGDEIYANCMVIDQVGDLDINYINIEGIPANTCLESMDSSLGPESSKAILPAEARAGTHPPSKDTEVTSHTEASAGTHPPSKSTEVTSHTEAQAPFVSSSSYASNLNLSFGPRGFEKEQSRLKKRSSSLDALDADSEGEGHSEQLHNCYTPVCQSSSRTGITSGDESDSFETNTESDFNISRTESFSLSSSLQLKESLFSGIRSRSYSCSSPKISLGKTRLIRDFTVCNSVEEQRAYSLPEPPRENRIQEEEWDKYIIPAKSESEKYKVSRTFSFFMNRMTSPRNKAKTKGKDAKDKEKLTRHQFVPGTFSGVLQCLVCDKTLLGKESFQCSNCNGNVHKVCKDAAPLCTKKFQEKYNKNKPQTVLGSSSFRDVPPPGLSLHPSSSMPIGLPTGRKEMAGQVHPLSRSVPGTSMESSRRPGASLESENDGSTWRSRSHSDEMLQPMGSSPSTDSFLTEDVVDSSLWSDLSGDAQEFEAESWSLVVDPSFCSQQEKDVIQRQDVIFELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHKHFFYSMKERRQESCVGNDRNFIINRIGDILVQQFSEENANKMKKIYGEFCSHHKEAVSLFKELQQNKKFQNFIKLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKESTEEQRDLCKALCLIKDMIAAVDLKVSEYEKKQKWLEILNKIENKTYTKLKNGHVFRKQALMSKERTLLYDGLVYWKTATGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQKLIAREVANEERGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVESCPEEEGGRTSESDEERRKAEARVAKIQQCQEMLSNQDQQICTYLEEKLHIYAKLGELSGYQDVHLEPHLLIQTDPGEPPQAASLLAAALKEAESLQVAVKASQMSDACQSPEEGCGEPALPDVLNSQDAPGLSTASLVTEGTGGRGCWDVDAGTQGVGTDLAVSDAGEKVEYRSFPGSLQSEIIQAIQNLTRLLYSLQAALTIQDSHIEIHRLVLQQRDSLAPGPAFRGSPFQDQKSRSLEKQQEELADTHKLQLQFQQDQHRWLRRCDQQQREQEARASRLQERERECRAQEELLLRSRGELDQQLQDYQQSLERLREGQRLVERERERMRAQQSLLHHWKHGRQSSLPAAFSPGTLEVMELNQSETLCHENSFFFNEALVQMSVNPLNKLTPPDIHQDAAHPPGVSHSGSARTSENQVDLKTDVSQPSDINHELWIAAGACHQIPPLHQSSKDSCKNDLNISQTAYPLLHDSNPHGPQLQTFIAEEKLNLQRVTRQDGETGNGAEENIVYL",
        "proteome": "UP000291000",
        "gene": "ARHGEF28",
        "go_terms": [
            {
                "identifier": "GO:0005085",
                "name": "guanyl-nucleotide exchange factor activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 4,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": false,
        "in_bfvd": false,
        "ida_accession": "f0b6b10bc46a5cc4746f01d2bc9b83deb5093dcb",
        "counters": {
            "domain_architectures": 2503,
            "entries": 32,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 6,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "ssf": 4,
                "cathgene3d": 4,
                "cdd": 3,
                "profile": 3,
                "smart": 3,
                "pfam": 3,
                "panther": 1,
                "prosite": 1,
                "interpro": 10
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 2503
        }
    }
}