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{
    "metadata": {
        "accession": "A0A3R7L4N0",
        "id": "A0A3R7L4N0_9TRYP",
        "source_organism": {
            "taxId": "83891",
            "scientificName": "Trypanosoma conorhini",
            "fullName": "Trypanosoma conorhini"
        },
        "name": "Bifunctional dihydrofolate reductase-thymidylate synthase",
        "description": [
            "Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP"
        ],
        "length": 521,
        "sequence": "MSLYKIRMPETAGEGTRLAMRAFSLVVAVDQHGGIGDGRSIPWNVPEDMKYFREVTTKLRGKKAKPSPAKRNAVVMGRKTWDSIPPNFRPLPGRLNVVLSSKLTTQQLLDGLPNEEKRKAAANNIVAVNGGLEQALRLLAAPIYTRSIETVFCIGGGSVYAEAIRSPCVGVLQAIHRTTICTSGPSCSVFFNLPETGTEVAGGIEWRRESITTELTSANAEGTNYYIEKLIPRNREEEQYLGLVDRIIREGALKRERTGVGAVSLFGAQMRFSLRNNRLPLLTTKRVFWRGVCEELLWFLRGETYAKKLSDKGVHIWDGNGSRAFLDSRGLTDYEEMDLGPVYGFQWRHFGADYTRHDANYDGKGVDQIKAIVETLRANPDDRRALFTAWNPSALPRMALPPCHLLGQFHVRDGELSCMLYQRSCDMGLGVPFNIASYALLTILIAKATGLRPGEFVHSLGDAHVYSNHIEPCQLQLKRVPRPFPFLIFHREREFLEDYEAEDMEVIDYTPYPTISMKMAV",
        "proteome": "UP000284403",
        "gene": "Tco025E_04040",
        "go_terms": [
            {
                "identifier": "GO:0004146",
                "name": "dihydrofolate reductase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0046654",
                "name": "tetrahydrofolate biosynthetic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0004799",
                "name": "thymidylate synthase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006730",
                "name": "one-carbon metabolic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0016741",
                "name": "transferase activity, transferring one-carbon groups",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006231",
                "name": "dTMP biosynthetic process",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "35b58e11181e3b27a65befb1b76d70e5d59a42e1",
        "counters": {
            "domain_architectures": 1743,
            "entries": 26,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 3,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 2,
                "ssf": 2,
                "profile": 1,
                "pfam": 2,
                "cdd": 2,
                "pirsf": 1,
                "panther": 1,
                "hamap": 1,
                "ncbifam": 2,
                "prosite": 2,
                "prints": 1,
                "interpro": 9
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 1743
        }
    }
}