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{
    "metadata": {
        "accession": "A0A3P9B6V2",
        "id": "A0A3P9B6V2_9CICH",
        "source_organism": {
            "taxId": "106582",
            "scientificName": "Maylandia zebra",
            "fullName": "Maylandia zebra (zebra mbuna)"
        },
        "name": "Sphingomyelin synthase-related protein 1",
        "description": [
            "Synthesizes sphingolipids through transfer of a phosphatidyl head group from a glycerophospholipid on to the primary hydroxyl of a ceramide in the lumen of the endoplasmic reticulum. Catalyzes the synthesis of ceramide phosphoethanolamines (CPEs) (such as N-acylsphing-4-enine 1-phosphoethanolamine) by transferring phosphoethanolamine head group, which is smaller and more hydrophilic than the phosphocholine (PC) headgroup transferred in the canonical sphingomyelin synthesis (SMS) reaction by SMS1 or SMS2, from a phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to a ceramide (such as N-acylsphing-4-enine). The larger PC prevents an efficient fit in the enzyme's catalytic pocket, leading to little or no SMS activity. In vitro, in the absence of ceramide, it has PLC activity with preference for phosphatidylinositol and phosphatidic acid, but also hydrolyzes phosphatidylethanolamine"
        ],
        "length": 429,
        "sequence": "MALSEDDVSAWSCKQVAQWLKEEGFGQYVELLCTQHRLDGLSLLALTEADLRGPPLGLTVLGDIKRLTIALRQLQRKNQAQLEELGLSPSDSLPAGLSTGTTGVKWSCDGADGCNGGDRLCNGTELRSRNSNRSGYSSGEVLCHTHSNGRCRQHLAGRLDPEVWKTVISSIYVFLVFGFTSFVMVIVHERVPDMRTYPPLPDIFLDSVPRIPWAFAMAEACGLILCYMFLLILLLHKHRSILFRRLCSLMGTVFLLRCCTMFATSLSVPGQHLKCASKTYGDTWGKIQRALTIWSGFGMTLTGVQTCGDYMFSGHTVVITMLNFFVTEYTPRTWNLIHTISWVLNLFGIFFILAAHEHYSIDVFIAFYITTRLFLYYHTLANTRAYQHSRRARIWFPMFSFFECNVNGPVPNQYHWPFSKPAFMKTLIG",
        "proteome": "UP000265160",
        "gene": null,
        "go_terms": [
            {
                "identifier": "GO:0005515",
                "name": "protein binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0016780",
                "name": "phosphotransferase activity, for other substituted phosphate groups",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "e54e3c28ea99d970cf062c6c875fbb0e1bf707ee",
        "counters": {
            "domain_architectures": 1790,
            "entries": 12,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 3,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "ssf": 1,
                "cathgene3d": 1,
                "smart": 1,
                "cdd": 1,
                "pfam": 2,
                "profile": 1,
                "panther": 1,
                "interpro": 4
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 1790
        }
    }
}