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{
"metadata": {
"accession": "A0A3B3URM1",
"id": "A0A3B3URM1_9TELE",
"source_organism": {
"taxId": "48699",
"scientificName": "Poecilia latipinna",
"fullName": "Poecilia latipinna (sailfin molly)"
},
"name": "Regulator of telomere elongation helicase 1",
"description": [
"A probable ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere"
],
"length": 1177,
"sequence": "MPSLNLRGVTVNFPFTPYECQKDYMSKVLQCLQEKSNGVLESPTGTGKTLCLLCATLAWREHFRDSISARRLADKLKGQELFPSTPLASWGTAATDGDKPTYYTDIPKIIYASRTHSQLAQVINELKNTSYRPKVCVLGSREQLCINQEVMRQESNHIKVHMCRGKVSTRSCQFYNNVDEKSTDRDLVNSILDVEDLVKFGNKQRVCPYYLSRSLKQQADVIFMPYNYLLDPKSRRAHNIELNGAVVIFDEAHNVEKTCEESTSFDLTPYDIASAITAVDRLLVEQAREVSQRDSVTEDHNVESLSSGLKIDISTIAKIKQILLDLETAIDSYEVPSDRGITKPGIFIYELLERAHLTYKTKTEIHDALEQIIGSLTGLPGIFLSTAGLQKLVDMIQLVFCGEPSDKDKQKQMEFNSAHFKVHIHLDNSYQKKKQTPDLWSAPSTSSKKQGNVLSYWCFSPGFSMQDLVNQEVRCVILTSGTLSPLTSFTSEMRIKFPVLLENGHVIERDQIFVSVIDRGPDGVHLSSAFDRRFNPDNMTSLGNTVANLSRVVPHGLLVFFPSFPLMEKTLEFWRANGHTDRIENMKPMFVEPKGKGTFNEVMDGYYNKVNDPASNGGSFFAVCRGKASEGLDFADTFGRGVIITGLPFPPKFDPRVVLKMQFLDEMSRKKSPGMRYLSGQEWYKQQAFRAVNQAIGRVIRHKEDYGAIFLCDQRFKSSDARAQLPSWVKPYVRLYDKFGNVVRDVSQFFRVAQKIRPVVVKIPTLETLPTECSSNTPSFSSGSASESYHTQKAKALDAHLPSLKRRKLDEQSRANGVAKLCIAYESEVQQSQRKPTNLLDALERGDRCWEEDVGEEKASRLSTLSLQYDKKMEDELRGGKRKIKLIQEQKASVSEDGSEESKAGRAKQFLADMKKSLSKVSFDHIVQALQSYKKTDDLSVLLTETAVLAEDPNTHSLFRGFYQFVRPHHKKTFDEKCQELLGQGCGFKPEHSLSKEEKKAVILQTAVDRQAVGTLSSRSTCGQLDTQQLNRGGRHLSQQGLRAAPSGSDHKSEIHAAFLADVKQALGPEKSAQLFQAIHGYKKTDDYDSLVTTVVSLFTERDENFHLLIRFGVFVRPRHKKRYKEMLDALIGQPVSAADSPAVSEEQPSAAPLSPPLKTQSKISSFFSNSERKSDP",
"proteome": "UP000261500",
"gene": "RTEL1",
"go_terms": [
{
"identifier": "GO:0005524",
"name": "ATP binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0003678",
"name": "DNA helicase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0016818",
"name": "hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0003676",
"name": "nucleic acid binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0004386",
"name": "helicase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006139",
"name": "nucleobase-containing compound metabolic process",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0000723",
"name": "telomere maintenance",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0006260",
"name": "DNA replication",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0006281",
"name": "DNA repair",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0006310",
"name": "DNA recombination",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0005634",
"name": "nucleus",
"category": {
"code": "C",
"name": "cellular_component"
}
},
{
"identifier": "GO:0003677",
"name": "DNA binding",
"category": {
"code": "F",
"name": "molecular_function"
}
}
],
"protein_evidence": 3,
"source_database": "unreviewed",
"is_fragment": false,
"in_alphafold": true,
"in_bfvd": false,
"ida_accession": "d08beff377e77c7fe755b93c1f9b9835ae0f25f1",
"counters": {
"domain_architectures": 445,
"entries": 26,
"isoforms": 0,
"proteomes": 1,
"sets": 6,
"structures": 0,
"taxa": 1,
"dbEntries": {
"profile": 1,
"smart": 2,
"ssf": 1,
"cathgene3d": 2,
"cdd": 3,
"pfam": 4,
"hamap": 1,
"panther": 1,
"ncbifam": 1,
"interpro": 10
},
"proteome": 1,
"taxonomy": 1,
"similar_proteins": 445
}
}
}
