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{
    "metadata": {
        "accession": "A0A2Y9FZP3",
        "id": "A0A2Y9FZP3_TRIMA",
        "source_organism": {
            "taxId": "127582",
            "scientificName": "Trichechus manatus latirostris",
            "fullName": "Trichechus manatus latirostris (Florida manatee)"
        },
        "name": "Receptor protein-tyrosine kinase",
        "description": [
            "In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth"
        ],
        "length": 1054,
        "sequence": "MELAAWCRWGLLFALLPPGAAGTQVCTGTDMKLQLPASPETHLDMLRHLYQGCQVVQGNLELTYLPANAGLSFLQDIQEVQGYVLIAHNQVRQVPLHRLRIVRGTQLFQDKFALAVLDNGDPPDHATLATGAVPEGLRELQLRSLTEILKGGIMIQRNPQLCYQETILWKDIFHKNNRLSLELVDANHSRPCRPCSPACKVPHCWGESSEDCQSLTRTLCASGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPPLVVYNTDTFESEINSEGRYTFGASCVVTCPYNYLSTDVGSCTLVCPLNNQEVTAEDGTQKCEKCSKPCAQVCYGLGREHLREVRAVTSANIQEFAGCEKIFGSLAFLPESFEGDPASNTAPLQPEQLRVFETLEEITGYLYISAWPDNLPDLSVFQNLRVIRGRVLHDGAYSLALQGLGISWLGLRSLRELSSGLALIHRNARLCFVHTVPWDQLFRNPHQALLHSANRPEDECEGEGLACYPLCAHGHCWGPGPTQCVNCSQYLRGQECVEECRVLQGLPREYVKDRHCLPCHPECQPQNGSETCFGLEADQCVACAHYKDSPFCVARCPSGVKPDLSFMPIWKFPDEEGTCQPCPINCTHSCVDLDEKGCPAEQRASHVTIITTVVGILLFMVVGLVLGIVIKRWRQKIRKYTMRRLLQETELVEPLTPSGALPNQAQMRILKETELRKVKVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLRENTSPKANKEILDEAYVMAGVGSPYVSRLLGICLTSTVQLVTQLMPYGCLLDHVREHRGRLGSQDLLNWCVQIAKGMSYLEDVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESILRRRFTHQSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMIDSECRPRFRELVAEFSRMARDPQRFVVIQNEDMGPASPLDSTFYRSLLEDDDMGDLVDAEEYLVPQQGFFCPDPTPGTGGTAHRRHRSSSTRNM",
        "proteome": "UP000248480",
        "gene": "ERBB2",
        "go_terms": [
            {
                "identifier": "GO:0004713",
                "name": "protein tyrosine kinase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0006468",
                "name": "protein phosphorylation",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0004672",
                "name": "protein kinase activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0005524",
                "name": "ATP binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0007169",
                "name": "cell surface receptor protein tyrosine kinase signaling pathway",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0016020",
                "name": "membrane",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "cd4a62199a66dacc5adb304c5db6d01bd5827658",
        "counters": {
            "domain_architectures": 4218,
            "entries": 40,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 6,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "cathgene3d": 5,
                "ssf": 3,
                "pfam": 5,
                "smart": 2,
                "cdd": 3,
                "profile": 1,
                "pirsf": 1,
                "panther": 1,
                "prosite": 2,
                "prints": 1,
                "interpro": 16
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 4218
        }
    }
}