General Handler

HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept

{
    "metadata": {
        "accession": "A0A2U4CPB2",
        "id": "A0A2U4CPB2_TURTR",
        "source_organism": {
            "taxId": "9739",
            "scientificName": "Tursiops truncatus",
            "fullName": "Tursiops truncatus (Atlantic bottle-nosed dolphin)"
        },
        "name": "Adhesion G-protein coupled receptor G6",
        "description": [
            "Adhesion G-protein coupled receptor (aGPCR) for steroid hormones, such as progesterone and 17alpha-hydroxyprogesterone (17OHP). Involved in many biological processes, such as myelination, sprouting angiogenesis, placenta, ear and cartilage development. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRG6 is coupled to G(i) G alpha proteins and mediates inhibition of adenylate cyclase. Also able to couple to G(q) G proteins. Involved in myelination of the peripheral nervous system: required for differentiation of promyelinating Schwann cells and for normal myelination of axons. Also acts as a regulator of body length and bone mass. Acts as a regulator of blood-brain barrier formation in the central nervous system vie its association with LRP1 and ITGB1"
        ],
        "length": 1250,
        "sequence": "MMFHSGRMWSCHSKWKPSSLLFLFALYIVYVPPSAWGCANCRVVLSNPSGTFTSPCYPNDYPNSQACMWTLRAPAGYIIQITFNDFDIEEAPNCIYDSLSLDNGESQTKFCGATAKGLSFNSSANEMHVSFSSDFSIQKKGFNASYIRVAVSLRNQKVILPQTLDTYQVSLAKSVSIPELRAFTLCFEATKIGKEDNEWTAFSYSDASFTQLLSFGKTKNGYFLSISGSKCLLNSALPVKDKEDIFTESFEQLCIVWNNSLGYVGVNFKRNYGAVSCDSTISKVIPGNGKLLLGSNQNEIASLKGDIYNFRLWNFAMNSKILFNLSCNVKGNVVDWQNDFWNIPTLALKAESNLSCGSYLIPLPAAELANCADLGTLCQATVNSPSTTPPTVTTNMPVTNKTDKQRNDGIIYRIFIEIQNILHHPEVKVQSKVAEWLNSTFQNWNYTVYVVNISFHLSTGEDKIKVRRSIVNDQRLVILALLVYNATNNPDLEGRTIQQKLLRNNESLDEGLRLHRVNVRRLGICHDDEDPKGYKWPAIQPSVYNAPCPGKPGFYASRTCHHDPANTSLAYWGPPDISNCSSEANEVANQILNLTGDGQTLNSANITSIVEQVKRIVNKEGNIDITLGSTLMNIFSNILTSPDRDLLESSSEALKTIDELAFKIDLHSTSHVNITTRNLALGVSSVSPETNEISNFSIGLPSNNESYFQMDFESGQMDPLASVILPPNLLENLSEEDSVLVKRAQFTFFNKTGLFQDVGTKKGTLVSYVMACSIGNITIQDLKDPVRIKIKHTRTQAVPYPICAFWDLNKNEGSGFWNTSGCVAHKDSDASETVCLCNHLTHFGILMDLQGTASQLDSKNTKVLTFITNIGCGISAIFSAATLLTYVAFEKLRRDYPSKILMNLSTALLFLNLLFLLDGWITSFHVDGLCTAIAALLHFFLLATFTWMGLEAIHMYIALVKVFNTYIRRYILKFCIIGWGLPALVVSIVLASRNQNEVYGKESYGKEQGDEFCWIKDPVIFYVTCAGYFGLMFFLNVAMFIVVMVQICGRNGKRSSRTLREEVLRNLRSVVSLTFLLGMTWGFAFFAWGPLNVPFMYLFSIFNSLQGLFIFIFHCAMKENVQKQWRRHLCCGRFRLADNSDWSKTATNIIKKSSDNLGKSLSSSSIGSNSTYLTSKSKYSSTTYFKRNSHTDNAPMDKSSSKLTHADGEQTSIIPVHQVIDKVKGYCNAHSDNFYKNIIMSDTFSHSTKF",
        "proteome": "UP000245320",
        "gene": "ADGRG6",
        "go_terms": [
            {
                "identifier": "GO:0004930",
                "name": "G protein-coupled receptor activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0007186",
                "name": "G protein-coupled receptor signaling pathway",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            },
            {
                "identifier": "GO:0016020",
                "name": "membrane",
                "category": {
                    "code": "C",
                    "name": "cellular_component"
                }
            },
            {
                "identifier": "GO:0004888",
                "name": "transmembrane signaling receptor activity",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            },
            {
                "identifier": "GO:0007166",
                "name": "cell surface receptor signaling pathway",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "protein_evidence": 3,
        "source_database": "unreviewed",
        "is_fragment": false,
        "in_alphafold": true,
        "in_bfvd": false,
        "ida_accession": "7fdecae750ec64943058f49773ea0a33d651b8fc",
        "counters": {
            "domain_architectures": 1232,
            "entries": 36,
            "isoforms": 0,
            "proteomes": 1,
            "sets": 5,
            "structures": 0,
            "taxa": 1,
            "dbEntries": {
                "ssf": 3,
                "cathgene3d": 4,
                "pfam": 6,
                "profile": 4,
                "smart": 3,
                "cdd": 1,
                "panther": 1,
                "prints": 1,
                "prosite": 1,
                "interpro": 12
            },
            "proteome": 1,
            "taxonomy": 1,
            "similar_proteins": 1232
        }
    }
}