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{
"metadata": {
"accession": "A0A2T7NRL6",
"id": "A0A2T7NRL6_POMCA",
"source_organism": {
"taxId": "400727",
"scientificName": "Pomacea canaliculata",
"fullName": "Pomacea canaliculata (Golden apple snail)"
},
"name": "Uncharacterized protein",
"description": [
"Multifunctional protein that encodes the first 3 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5), aspartate transcarbamylase (ATCase; EC 2.1.3.2) and dihydroorotase (DHOase; EC 3.5.2.3). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate. In the last step, DHOase catalyzes the cyclization of carbamoyl aspartate to dihydroorotate"
],
"length": 2232,
"sequence": "MTRVKSATLYLEDGSCYEANLFGAAVSTSGEVVFQTGMVGYPESLTDPSYKRQILILTYPLIGNYGIASDELDKFGLKRWFESNTIHAAALVVADVTDNYSHWSASKSLSQWLAEHNIPGLYGVDTRALTKKIREKGSLLGKIIVHGDDPNSIAMEDPNVLNLVEEVSLKSPVTYNPSGEVQIVAVDCGMKFHQIRCLCERGAAVTVVPWNHPLTGLEFDGIFLSNGPGDPTMCQATINSVQNLLNREDYKPIFGICLGHQLLSLAIGARTYKMKYGNRGHNQPCLYEDTIRCYITTQNHGFAVDTQSLPKGWLPLFTNANDLTNEGIIHETKPFFSVQFHPENMAGPQDLEFLFDVFLDTVKSNKKGCVSPTVKERLRQAVHLKDVPLYPLKTPHPKKVLVLGSGGLSIGQAGEFDYSGSQAIKALKEEGVQTVLINPNIATVQTSQGLADKVYFLPITPDYVTQVIKCEKPDGILLTFGGQTALNCGIQLTRTGVLERNEVKVLGTQVSSIEWTEDRKVFADKMAEINEAVAPSEAAYSVEQAVQAAETLGYPVLVRAAFALGGLGSGFASNREELIALVTSAFAHTSQVLVDKSLKGWKEVEYEVVRDAYDNCITVCNMENVDPLGIHTGESIVVAPSQTLTNMEYNLLRTTALKVIRHLGIVGECNIQYALSPFSQQYYIIEVNARLSRSSALASKATGYPLAYVAAKLALGIPLPQLRNSVTGSTTACFEPSLDYCVVKVPRWDLRKFSRVSNKIGSSMKSVGEVMAIGCKFEEAFQKALRMMDESVMGFYPNTEEASEKELSDPTDKRIFVLGAALAAGYSIDRLYELTNIDRWFLHKFKKITDHYHLMENYRGKSKELPTDIMLQAKQMGFSDKQIAKAVARTELAVRMARNLQGVVPWVRQIDTVAAEWPASTNYLYLTYNAAQHDLLFPGGYVIVVGSGVYRIGSSVEFDWCAVNCIRQLRKMGYKTIMINYNPETVSTDYDMCDRLYFDEISFEVVMDIYSVENPEGVILSMGGQLPNNIAMDLHRQQVKILGTSAESIDNAENRFKFSRMLDTVGISQPQWKELSTTESAIAFCKEVGFPCLVRPSYVLSGAAMNVAHSVVDLENYLTQASAVSKEHPVVTSKFILEAKEIDVDAVASDGKVVCMAVSEHVENAGVHSGDATLVTPPQDLNEETLAKIKAICLAIGGALGVTGPFNIQLIAKDNQLKVIECNVRVSRSFPFVSKALDHDFIATATRVIMGETVEPVNVLYGCGRVAVKVPVFSFSRLQGADVLLGVEMASTGEVACFGEDRYEAYLKAQISTGFQIPRKNILLSIGSFKSKMELIPTVRSLIEMGYNLFASLGTADFYNEHGFKVTAVDWPYEDTGEDSANGEQRTIADYLSEHMVDLVINLPLRNGGSYRASSFVTQGYKTRRMAIDYCVPLFTDVKCTKMFVEALRRVKGIPPLKTHIDCISSKRIIRLPGLIDVHVHVREPGATHKEDWASATKAALAGGVTMILAMPNTTPPTVDSSALALTQKLARQSAYCDYGLYIGASNQNFTTAPNLASQAVALKMYLNETFTTLRLDDICVWIKHFEHWPRNIPICAHAEGATTAAILFIADLFQRPVHICHVARKAEILVVRAAKEKGLPVTCEVTPHHLFLTAADAERLGGGRGKVCPSLVSQEDQQALWDNMDIIDCFATDHAPHSVEEKDSQKPPPGFPGLETMLPLLLTADIIAKLHTNPRRIFNLPEQPDTYVEVDIETTWTIPDAMTYTKSHWTPFAGHQVTGMVRRVVLRGETAFIDGQVLTQPGFGQDVRTLPAPPVLPAAPDQPLTIQIPSGMVSQNVSEPNSPRKIIPMPLQSIQLSVVPSHIPPYLRADLRDIHVSHPDLKRDLMSQLGGPIVGHPSVSMPLSEPASHVPHHLQQVSLPQYIPGITNHHILSVSIFNKDQLSHIFNLAHNYRVAVMKDRPLDHVLKGKVLASMFYEASTRTSCSFTAAMERLGGRVIPFNEATSSAKKGETLEDTVVMMAGYCDVLVVRHPIADSVQKAAKVSRKPVINAGDGTGEHPTQALLDIFTIREEIGTVNELTITMVGDLKNGRTVHSLARLLALYRVSIRYVAPAELQMPRDIQNYLRSQKIPQETFDKLEDALPDTDVLYMTRIQKERFSSLEEYNKMCGHYIVTPELMTVAKRRMVVMHPLPRVDEISTTFDTDPRAAYFRQAENGMYVRMALLALVLGKC",
"proteome": "UP000245119",
"gene": "C0Q70_17066",
"go_terms": [
{
"identifier": "GO:0005524",
"name": "ATP binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0046872",
"name": "metal ion binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0016787",
"name": "hydrolase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0016810",
"name": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0016597",
"name": "amino acid binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0016743",
"name": "carboxyl- or carbamoyltransferase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006520",
"name": "amino acid metabolic process",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0004088",
"name": "carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006207",
"name": "'de novo' pyrimidine nucleobase biosynthetic process",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0006541",
"name": "glutamine metabolic process",
"category": {
"code": "P",
"name": "biological_process"
}
},
{
"identifier": "GO:0004070",
"name": "aspartate carbamoyltransferase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0016812",
"name": "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides",
"category": {
"code": "F",
"name": "molecular_function"
}
}
],
"protein_evidence": 3,
"source_database": "unreviewed",
"is_fragment": false,
"in_alphafold": false,
"in_bfvd": false,
"ida_accession": "03681b2eb21ae5af708b0bd384fd15f535bdb129",
"counters": {
"domain_architectures": 569,
"entries": 81,
"isoforms": 0,
"proteomes": 1,
"sets": 9,
"structures": 0,
"taxa": 1,
"dbEntries": {
"cathgene3d": 9,
"smart": 3,
"ssf": 9,
"pfam": 9,
"profile": 3,
"cdd": 3,
"hamap": 2,
"ncbifam": 7,
"panther": 1,
"prints": 4,
"prosite": 5,
"interpro": 26
},
"proteome": 1,
"taxonomy": 1,
"similar_proteins": 569
}
}
}
